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Japanese Journal of Ophthalmology
Published in: Japanese Journal of Ophthalmology 4/2013

01-07-2013 | Clinical Investigation

Clinical features of human T lymphotropic virus type 1-associated uveitis in Hokkaido, Japan

Authors: Satoru Kase, Kenichi Namba, Nobuyoshi Kitaichi, Daiju Iwata, Shigeaki Ohno, Susumu Ishida

Published in: Japanese Journal of Ophthalmology | Issue 4/2013

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Abstract

Purpose

To clarify the clinical features of human lymphotropic virus type 1 (HTLV-1)-associated uveitis (HAU) in patients of Hokkaido University Hospital, Hokkaido, northern Japan.

Methods

We reviewed the records of a consecutive series of 21 patients with HAU who were followed up for more than 12 months at Hokkaido University Hospital.

Results

Of the 21 patients enrolled in this study, 19 as well as their parents (90.5 %) were born in Hokkaido. One patient was a member of the Ainu ethnic group. Unilateral involvement was found in 16 cases (76 %). In the ophthalmological examinations, vitreous opacity was most frequently followed by keratic precipitate, iris/gonio nodules, and posterior synechiae, while hypopyon, retinal vasculitis, and neovascularization were rarely observed. Intraocular inflammation was controlled by topical treatment, while systemic corticosteroids were required in less than one-fourth of patients. Visual acuity improved in 15 patients, remained unchanged in four patients, and deteriorated in two patients. HAU was observed in two patients with adult T-cell leukemia/lymphoma (ATLL). Three out of the four patients (75 %) for whom HLA typing was available had HLA-A26.

Conclusions

A number of clinical features were unique to Hokkaido, namely, predominant unilateral involvement, as well as two HAU patients with ATLL. The phylogenetic difference of HTLV-1 and HLA typing may correlate with different clinical manifestations in HAU.
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Metadata
Title
Clinical features of human T lymphotropic virus type 1-associated uveitis in Hokkaido, Japan
Authors
Satoru Kase
Kenichi Namba
Nobuyoshi Kitaichi
Daiju Iwata
Shigeaki Ohno
Susumu Ishida
Publication date
01-07-2013
Publisher
Springer Japan
Published in
Japanese Journal of Ophthalmology / Issue 4/2013
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-013-0244-x

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