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Japanese Journal of Ophthalmology

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01-07-2013 | Clinical Investigation

Dry eye and tear film functions in patients with psoriasis

Authors: Young Her, Ji Won Lim, Sang Hak Han

Published in: Japanese Journal of Ophthalmology | Issue 4/2013

Abstract

Purpose

To evaluate dry eye symptoms, tear film function and ocular surface changes in patients with psoriasis.

Methods

The Dry Eye Questionnaire and ophthalmic examination including the Schirmer test, tear break-up time, corneal fluorescein test, meibomian gland obstruction and conjunctival impression cytology were assessed in patients with chronic plaque psoriasis. Results were compared between 30 patients and 30 healthy controls.

Results

The rate of positive responses in the Dry Eye Questionnaire and staining of corneal fluorescein test were significantly higher in the patients (P = 0.030) than in the controls (P = 0.012). The tear break-up time in patients was significantly lower than in the controls (P < 0.001). However, there were no differences in the Schirmer test and meibomian gland function between the patients and controls. In the impression cytology analysis, more cell alteration and decreased goblet cell density were observed in the patients (P < 0.001) compared with those obtained from controls (P = 0.003).

Conclusions

The dry eye symptom was more common in patients with psoriasis. In addition, the patients showed a higher tear film instability and significant degeneration on the ocular surface when compared with the normal controls.

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Title: Dry eye and tear film functions in patients with psoriasis
Authors: Young Her
Ji Won Lim
Sang Hak Han
Publication date: 01-07-2013
Publisher: Springer Japan
Published in: Japanese Journal of Ophthalmology / Issue 4/2013
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-012-0226-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dry eye and tear film functions in patients with psoriasis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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