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Published in:

01-06-2006

POSSUM Predicts Decreased Overall Survival in Curative Resection for Colorectal Cancer

Authors: Rebecca P. Brosens, M.D., Joannes L. Oomen, M.D., Afina S. Glas, Ph.D., Aart van Bochove, Ph.D., Miguel A. Cuesta, Ph.D., Alexander F. Engel, Ph.D.

Published in: Diseases of the Colon & Rectum | Issue 6/2006

Purpose

Poor condition at operation determined by the physiologic POSSUM score is related to postoperative mortality and morbidity of colorectal cancer surgery. This study was designed to analyze the relationship between condition of patients with colorectal cancer at operation and long-term overall survival.

Methods

A total of 542 patients survived a radical resection for Stages I, II, or III colorectal cancer. Physiologic POSSUM score at surgery, exclusive of age, was calculated for all patients. Mean physiologic POSSUM score was used as cutoff point to determine low-risk and high-risk group patients. A Cox proportional hazard analysis was performed to study the effect of low-risk and high-risk group on overall survival and to identify independent risk factors.

Results

Five-year overall survival was significantly higher in low-risk group patients than in high-risk group patients (low-risk group 66.6 percent vs. high-risk group 48.5 percent; P < 0.001). Differences in overall survival also were found when patients in Stages I, II, and III were analyzed separately. Risk factors for overall survival were advanced stage of disease, poor tumor differentiation, mucinous adenocarcinoma, older than age 70 years, and poor condition of the patient at time of operation.

Conclusions

Poor condition at operation, as determined by physiologic POSSUM score, is a risk indicator for long-term overall survival in colorectal cancer patients.

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Title: POSSUM Predicts Decreased Overall Survival in Curative Resection for Colorectal Cancer
Authors: Rebecca P. Brosens, M.D.
Joannes L. Oomen, M.D.
Afina S. Glas, Ph.D.
Aart van Bochove, Ph.D.
Miguel A. Cuesta, Ph.D.
Alexander F. Engel, Ph.D.
Publication date: 01-06-2006
Publisher: Springer-Verlag
Published in: Diseases of the Colon & Rectum / Issue 6/2006
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI: https://doi.org/10.1007/s10350-005-0284-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

POSSUM Predicts Decreased Overall Survival in Curative Resection for Colorectal Cancer

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Purpose

Methods

Results

Conclusions

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