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Magnetic Resonance Materials in Physics, Biology and Medicine

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20-10-2023 | Magnetic Resonance Imaging | Research Article

Synthesis and evaluation of new magneto-fluorescent carbon dot based on manganese citrate for MRI imaging

Authors: Vahid Ali, Hassan Kefayati, Mehdi Shafiee Ardestani, Afshin Pourahmad

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2024

Abstract

Objective

Medical imaging techniques have widely revolutionized the diagnosis and treatment of various health conditions. Among these techniques, magnetic resonance imaging (MRI) has stood out as a noninvasive and versatile tool. Now, a breakthrough innovation called “manganese-carbon dots” is poised to enhance MRI imaging and provide physicians with even greater insight into the human body.

Materials and methods

In this study, one-pot hydrothermal method was used to fabricate magneto-fluorescent carbon quantum dots using manganese citrate, urea, and Mn2+. Manganese citrateAQ3 acted as a carbon source and contrast agent. TEM,XPS, FTIR, UV–Vis, fluorescent analysis confirmed the successful synthesis of magneto-fluorescent carbon quantum dots. The MTT assay was used to study its biocompatiblity, Finallay application of itscompound for mri imaging was investigated.

Results

Characterization Techniques confirmed the succesful synthesis of product. MTT assay showed no toxicity of this product on HEK-293 cells. In addition, it exhibited high r1 relaxivity (7.4 mM–1 S−1) suggesting excellent potential of magneto-fluorescent carbon quantum dots as MRI T1 contrast agent and enabling specific imaging.

Conclusion

Based on the results obtained, the synthesized carbon quantum dots could be used as fluorescence/MRI bimodal platform for in vivo imaging.

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Title: Synthesis and evaluation of new magneto-fluorescent carbon dot based on manganese citrate for MRI imaging
Authors: Vahid Ali
Hassan Kefayati
Mehdi Shafiee Ardestani
Afshin Pourahmad
Publication date: 20-10-2023
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2024
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-023-01117-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Synthesis and evaluation of new magneto-fluorescent carbon dot based on manganese citrate for MRI imaging

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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