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Magnetic Resonance Materials in Physics, Biology and Medicine

Open Access 22-09-2023 | Research Article

First implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain

Authors: Louise Ebersberger, Fabian J. Kratzer, Vanessa L. Franke, Armin M. Nagel, Sebastian C. Niesporek, Andreas Korzowski, Mark E. Ladd, Heinz-Peter Schlemmer, Daniel Paech, Tanja Platt

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine

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Abstract

Objective

First implementation of dynamic oxygen-17 (17O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain.

Methods

Five healthy volunteers underwent a three-phase 17O gas (17O2) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute 17O water (H217O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm.

Results

The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of 17O MR data resulted in high signal fluctuations with a noise level of 10% due to small regions of interest (ROI), impeding further quantitative analysis. Statistical evaluation of the relative H217O signal with PV correction (p = 0.168) and without (p = 0.382) did not show significant difference between the stimulated left and non-stimulated right sensorimotor ROI.

Discussion

The change of cerebral oxygen metabolism induced by sensorimotor and visual stimulation is not large enough to be reliably detected with the current setup and methodology of dynamic 17O MRI at 7 T.
Appendix
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Metadata
Title
First implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain
Authors
Louise Ebersberger
Fabian J. Kratzer
Vanessa L. Franke
Armin M. Nagel
Sebastian C. Niesporek
Andreas Korzowski
Mark E. Ladd
Heinz-Peter Schlemmer
Daniel Paech
Tanja Platt
Publication date
22-09-2023
Publisher
Springer International Publishing
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-023-01119-6