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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-10-2017 | Research Article

Validation of an active shape model-based semi-automated segmentation algorithm for the analysis of thigh muscle and adipose tissue cross-sectional areas

Authors: Jana Kemnitz, Felix Eckstein, Adam G. Culvenor, Anja Ruhdorfer, Torben Dannhauer, Susanne Ring-Dimitriou, Alexandra M. Sänger, Wolfgang Wirth

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 5/2017

Abstract

Objective

To validate a semi-automated method for thigh muscle and adipose tissue cross-sectional area (CSA) segmentation from MRI.

Materials and methods

An active shape model (ASM) was trained using 113 MRI CSAs from the Osteoarthritis Initiative (OAI) and combined with an active contour model and thresholding-based post-processing steps. This method was applied to 20 other MRIs from the OAI and to baseline and follow-up MRIs from a 12-week lower-limb strengthening or endurance training intervention (n = 35 females). The agreement of semi-automated vs. previous manual segmentation was assessed using the Dice similarity coefficient and Bland-Altman analyses. Longitudinal changes observed in the training intervention were compared between semi-automated and manual segmentations.

Results

High agreement was observed between manual and semi-automated segmentations for subcutaneous fat, quadriceps and hamstring CSAs. With strength training, both the semi-automated and manual segmentation method detected a significant reduction in adipose tissue CSA and a significant gain in quadriceps, hamstring and adductor CSAs. With endurance training, a significant reduction in adipose tissue CSAs was observed with both methods.

Conclusion

The semi-automated approach showed high agreement with manual segmentation of thigh muscle and adipose tissue CSAs and showed longitudinal training effects similar to that observed using manual segmentation.

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Title: Validation of an active shape model-based semi-automated segmentation algorithm for the analysis of thigh muscle and adipose tissue cross-sectional areas
Authors: Jana Kemnitz
Felix Eckstein
Adam G. Culvenor
Anja Ruhdorfer
Torben Dannhauer
Susanne Ring-Dimitriou
Alexandra M. Sänger
Wolfgang Wirth
Publication date: 01-10-2017
Publisher: Springer Berlin Heidelberg
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 5/2017
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-017-0622-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Validation of an active shape model-based semi-automated segmentation algorithm for the analysis of thigh muscle and adipose tissue cross-sectional areas

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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