Skip to main content
Top
Published in: The European Journal of Health Economics 4/2015

01-05-2015 | Original Paper

Cost-effectiveness of integrated care in frail elderly using the ICECAP-O and EQ-5D: does choice of instrument matter?

Authors: Peter Makai, Willemijn Looman, Eddy Adang, René Melis, Elly Stolk, Isabelle Fabbricotti

Published in: The European Journal of Health Economics | Issue 4/2015

Login to get access

Abstract

Economic evaluations likely undervalue the benefits of interventions in populations receiving both health and social services, such as frail elderly, by measuring only health-related quality of life. For this reason, alternative preference-based instruments have been developed for economic evaluations in the elderly, such as the ICECAP-O. The aim of this paper is twofold: (1) to evaluate the cost-effectiveness using a short run time frame for an integrated care model for frail elderly, and (2) to investigate whether using a broader measure of (capability) wellbeing in an economic evaluation leads to a different outcome in terms of cost-effectiveness. We performed univariate and multivariate analyses on costs and outcomes separately. We also performed incremental net monetary benefit regressions using quality adjusted life years (QALYs) based on the ICECAP-O and EQ-5D. In terms of QALYs as measured with the EQ-5D and the ICECAP-O, there were small and insignificant differences between the instruments, due to negligible effect size. Therefore, widespread implementation of the Walcheren integrated care model would be premature based on these results. All results suggest that, using the ICECAP-O, the intervention has a higher probability of cost-effectiveness than with the EQ-5D at the same level of WTP. In case an intervention’s health and wellbeing effects are not significant, as in this study, using the ICECAP-O will not lead to a false claim of cost-effectiveness of the intervention. On the other hand, if differences in capability QALYs are meaningful and significant, the ICECAP-O may have the potential to measure broader outcomes and be more sensitive to differences between intervention and comparators.
Appendix
Available only for authorised users
Literature
1.
go back to reference Drummond, M.F., Sculpher, M.J., Torrance, G.W., O’Brien, B.J., Stoddart, G.L.: Methods for the economic evaluation of health care programmes, 3rd edn. Oxford University Press, Oxford (2005) Drummond, M.F., Sculpher, M.J., Torrance, G.W., O’Brien, B.J., Stoddart, G.L.: Methods for the economic evaluation of health care programmes, 3rd edn. Oxford University Press, Oxford (2005)
4.
go back to reference Sen, A.: Choice, welfare and measurement. Harvard University Press, Cambridge (1982) Sen, A.: Choice, welfare and measurement. Harvard University Press, Cambridge (1982)
10.
go back to reference Coast, J., Flynn, T., Sutton, E., Al-Janabi, H., Vosper, J., Lavender, S., Louviere, J., Peters, T.: Investigating choice experiments for preferences of older people (ICEPOP): evaluative spaces in health economics. J. Health Serv. Res. Policy 13(Suppl 3), 31–37 (2008). doi:10.1258/jhsrp.2008.008024 PubMedCrossRef Coast, J., Flynn, T., Sutton, E., Al-Janabi, H., Vosper, J., Lavender, S., Louviere, J., Peters, T.: Investigating choice experiments for preferences of older people (ICEPOP): evaluative spaces in health economics. J. Health Serv. Res. Policy 13(Suppl 3), 31–37 (2008). doi:10.​1258/​jhsrp.​2008.​008024 PubMedCrossRef
11.
go back to reference Makai, P., Brouwer, W.B.F., Koopmanschap, M.A., Stolk, E.A., Nieboer, A.P.: Quality of life instruments for economic evaluations in health and social care for older people: a systematic review. Soc. Sci. Med. 102, 10 (2014)CrossRef Makai, P., Brouwer, W.B.F., Koopmanschap, M.A., Stolk, E.A., Nieboer, A.P.: Quality of life instruments for economic evaluations in health and social care for older people: a systematic review. Soc. Sci. Med. 102, 10 (2014)CrossRef
12.
go back to reference Coast, J., Peters, T.J., Natarajan, L., Sproston, K., Flynn, T.: An assessment of the construct validity of the descriptive system for the ICECAP capability measure for older people. Qual. Life Res.: Int. J. Qual. Life Asp. Treat. Care Rehabil. 17(7), 967–976 (2008)CrossRef Coast, J., Peters, T.J., Natarajan, L., Sproston, K., Flynn, T.: An assessment of the construct validity of the descriptive system for the ICECAP capability measure for older people. Qual. Life Res.: Int. J. Qual. Life Asp. Treat. Care Rehabil. 17(7), 967–976 (2008)CrossRef
13.
go back to reference Makai, P., Koopmanschap, M.A., Brouwer, W.B.F., Nieboer, A.P.: A validation of the ICECAP-O in a population of post-hospitalized older people. Health Qual. Life Outcomes 11(57), 1–11 (2013) Makai, P., Koopmanschap, M.A., Brouwer, W.B.F., Nieboer, A.P.: A validation of the ICECAP-O in a population of post-hospitalized older people. Health Qual. Life Outcomes 11(57), 1–11 (2013)
14.
go back to reference Makai, P., Brouwer, W.B., Koopmanschap, M.A., Nieboer, A.P.: Capabilities and quality of life in Dutch psycho-geriatric nursing homes: an exploratory study using a proxy version of the ICECAP-O. Qual. Life Res. 21(5), 801–812 (2012)PubMedCentralPubMedCrossRef Makai, P., Brouwer, W.B., Koopmanschap, M.A., Nieboer, A.P.: Capabilities and quality of life in Dutch psycho-geriatric nursing homes: an exploratory study using a proxy version of the ICECAP-O. Qual. Life Res. 21(5), 801–812 (2012)PubMedCentralPubMedCrossRef
15.
go back to reference Couzner, L., Ratcliffe, J., Crotty, M.: The relationship between quality of life, health and care transition: an empirical comparison in an older post-acute population. Health Qual. Life Outcomes 10(1), 69 (2012)PubMedCentralPubMedCrossRef Couzner, L., Ratcliffe, J., Crotty, M.: The relationship between quality of life, health and care transition: an empirical comparison in an older post-acute population. Health Qual. Life Outcomes 10(1), 69 (2012)PubMedCentralPubMedCrossRef
16.
go back to reference Couzner, L., Ratcliffe, J., Lester, L., Flynn, T., Crotty, M.: Measuring and valuing quality of life for public health research: application of the ICECAP-O capability index in the Australian general population. Int. J. Public Health 58(3), 367–376 (2013)PubMedCrossRef Couzner, L., Ratcliffe, J., Lester, L., Flynn, T., Crotty, M.: Measuring and valuing quality of life for public health research: application of the ICECAP-O capability index in the Australian general population. Int. J. Public Health 58(3), 367–376 (2013)PubMedCrossRef
17.
go back to reference Davis, J.C., Liu-Ambrose, T., Richardson, C.G., Bryan, S.: A comparison of the ICECAP-O with EQ-5D in a falls prevention clinical setting: Are they complements or substitutes? Qual. Life Res. 22(5), 969–977 (2013)PubMedCentralPubMedCrossRef Davis, J.C., Liu-Ambrose, T., Richardson, C.G., Bryan, S.: A comparison of the ICECAP-O with EQ-5D in a falls prevention clinical setting: Are they complements or substitutes? Qual. Life Res. 22(5), 969–977 (2013)PubMedCentralPubMedCrossRef
18.
go back to reference Davis, J.C., Bryan, S., McLeod, R., Rogers, J., Khan, K., Liu-Ambrose, T.: Exploration of the association between quality of life, assessed by the EQ-5D and ICECAP-O, and falls risk, cognitive function and daily function, in older adults with mobility impairments. BMC Geriatr. 12(1), 65 (2012)PubMedCentralPubMedCrossRef Davis, J.C., Bryan, S., McLeod, R., Rogers, J., Khan, K., Liu-Ambrose, T.: Exploration of the association between quality of life, assessed by the EQ-5D and ICECAP-O, and falls risk, cognitive function and daily function, in older adults with mobility impairments. BMC Geriatr. 12(1), 65 (2012)PubMedCentralPubMedCrossRef
19.
go back to reference Mitchell, P.M., Roberts, T.E., Barton, P.M., Pollard, B.S., Coast, J.: Predicting the ICECAP-O capability index from the WOMAC osteoarthritis index is mapping onto capability from condition-specific health status questionnaires feasible? Med. Decis. Mak. 33(4), 547–557 (2013)CrossRef Mitchell, P.M., Roberts, T.E., Barton, P.M., Pollard, B.S., Coast, J.: Predicting the ICECAP-O capability index from the WOMAC osteoarthritis index is mapping onto capability from condition-specific health status questionnaires feasible? Med. Decis. Mak. 33(4), 547–557 (2013)CrossRef
20.
go back to reference Comans, T.A., Peel, N.M., Gray, L.C., Scuffham, P.A.: Quality of life of older frail persons receiving a post-discharge program. Health Qual. Life Outcomes 11(1), 58 (2013)PubMedCentralPubMedCrossRef Comans, T.A., Peel, N.M., Gray, L.C., Scuffham, P.A.: Quality of life of older frail persons receiving a post-discharge program. Health Qual. Life Outcomes 11(1), 58 (2013)PubMedCentralPubMedCrossRef
21.
go back to reference Makai, P., Beckebans, F., van Exel, J., Brouwer, W.B.: Quality of life of nursing home residents with dementia: validation of the German version of the ICECAP-O. PLoS ONE 9(3), e92016 (2014)PubMedCentralPubMedCrossRef Makai, P., Beckebans, F., van Exel, J., Brouwer, W.B.: Quality of life of nursing home residents with dementia: validation of the German version of the ICECAP-O. PLoS ONE 9(3), e92016 (2014)PubMedCentralPubMedCrossRef
22.
go back to reference Henderson, C., Knapp, M., Fernández, J.-L., Beecham, J., Hirani, S.P., Cartwright, M., Rixon, L., Beynon, M., Rogers, A., Bower, P., Doll, H., Fitzpatrick, R., Steventon, A., Bardsley, M., Hendy, J., Newman, S.P.: Cost effectiveness of telehealth for patients with long term conditions (whole systems demonstrator telehealth questionnaire study): nested economic evaluation in a pragmatic, cluster randomised controlled trial. BMJ 346 (2013). doi:10.1136/bmj.f1035 Henderson, C., Knapp, M., Fernández, J.-L., Beecham, J., Hirani, S.P., Cartwright, M., Rixon, L., Beynon, M., Rogers, A., Bower, P., Doll, H., Fitzpatrick, R., Steventon, A., Bardsley, M., Hendy, J., Newman, S.P.: Cost effectiveness of telehealth for patients with long term conditions (whole systems demonstrator telehealth questionnaire study): nested economic evaluation in a pragmatic, cluster randomised controlled trial. BMJ 346 (2013). doi:10.​1136/​bmj.​f1035
23.
go back to reference Rockwood, K., Song, X., MacKnight, C., Bergman, H., Hogan, D.B., McDowell, I., Mitnitski, A.: A global clinical measure of fitness and frailty in elderly people. Can. Med. Assoc. J. 173(5), 489–495 (2005). doi:10.1503/cmaj.050051 CrossRef Rockwood, K., Song, X., MacKnight, C., Bergman, H., Hogan, D.B., McDowell, I., Mitnitski, A.: A global clinical measure of fitness and frailty in elderly people. Can. Med. Assoc. J. 173(5), 489–495 (2005). doi:10.​1503/​cmaj.​050051 CrossRef
24.
go back to reference Ferrucci, L., Guralnik, J.M., Studenski, S., Fried, L.P., Cutler, G.B., Walston, J.D., The Interventions on Frailty Working G: Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J. Am. Geriatr. Soc. 52(4), 625–634 (2004). doi:10.1111/j.1532-5415.2004.52174.x PubMedCrossRef Ferrucci, L., Guralnik, J.M., Studenski, S., Fried, L.P., Cutler, G.B., Walston, J.D., The Interventions on Frailty Working G: Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J. Am. Geriatr. Soc. 52(4), 625–634 (2004). doi:10.​1111/​j.​1532-5415.​2004.​52174.​x PubMedCrossRef
25.
go back to reference Djernes, J.: Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr. Scand. 113(5), 372–387 (2006)PubMedCrossRef Djernes, J.: Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr. Scand. 113(5), 372–387 (2006)PubMedCrossRef
26.
go back to reference Eklund, K., Wilhelmson, K.: Outcomes of coordinated and integrated interventions targeting frail elderly people: a systematic review of randomised controlled trials. Health Soc. Care Commun. 17(5), 447–458 (2009)CrossRef Eklund, K., Wilhelmson, K.: Outcomes of coordinated and integrated interventions targeting frail elderly people: a systematic review of randomised controlled trials. Health Soc. Care Commun. 17(5), 447–458 (2009)CrossRef
27.
go back to reference Melis, R., van Eijken, M., Teerenstra, S., van Achterberg, T., Parker, S., Borm, G., van de Lisdonk, E., Wensing, M., Rikkert, M.: A randomized study of a multidisciplinary program to intervene on geriatric syndromes in vulnerable older people who live at home (Dutch EASYcare Study). J. Gerontol. A. 63(3), 283 (2008)CrossRef Melis, R., van Eijken, M., Teerenstra, S., van Achterberg, T., Parker, S., Borm, G., van de Lisdonk, E., Wensing, M., Rikkert, M.: A randomized study of a multidisciplinary program to intervene on geriatric syndromes in vulnerable older people who live at home (Dutch EASYcare Study). J. Gerontol. A. 63(3), 283 (2008)CrossRef
28.
go back to reference Fabbricotti, I.N., Janse, B., Looman, W.M., de Kuijper, R., van Wijngaarden, J.D., Reiffers, A.: Integrated care for frail elderly compared to usual care: a study protocol of a quasi-experiment on the effects on the frail elderly, their caregivers, health professionals and health care costs. BMC Geriatr. 13(1), 31 (2013)PubMedCentralPubMedCrossRef Fabbricotti, I.N., Janse, B., Looman, W.M., de Kuijper, R., van Wijngaarden, J.D., Reiffers, A.: Integrated care for frail elderly compared to usual care: a study protocol of a quasi-experiment on the effects on the frail elderly, their caregivers, health professionals and health care costs. BMC Geriatr. 13(1), 31 (2013)PubMedCentralPubMedCrossRef
29.
go back to reference Looman, W., Fabbricotti, I.: The effects of an integrated care model on frail elderly. Int. J. Integr. Care 12(Suppl3), e153 (2012) Looman, W., Fabbricotti, I.: The effects of an integrated care model on frail elderly. Int. J. Integr. Care 12(Suppl3), e153 (2012)
30.
go back to reference Schuurmans, H., Steverink, N., Lindenberg, S., Frieswijk, N., Slaets, J.P.: Old or frail: What tells us more? J. Gerontol. A. 59(9), M962–M965 (2004)CrossRef Schuurmans, H., Steverink, N., Lindenberg, S., Frieswijk, N., Slaets, J.P.: Old or frail: What tells us more? J. Gerontol. A. 59(9), M962–M965 (2004)CrossRef
31.
go back to reference Johri, M., Beland, F., Bergman, H.: International experiments in integrated care for the elderly: a synthesis of the evidence. Int. J. Geriatr. Psychiatry 18(3), 222–235 (2003)PubMedCrossRef Johri, M., Beland, F., Bergman, H.: International experiments in integrated care for the elderly: a synthesis of the evidence. Int. J. Geriatr. Psychiatry 18(3), 222–235 (2003)PubMedCrossRef
32.
go back to reference Schäfer, W., Kroneman, M., Boerma, W., van den Berg, M., Westert, G., Devillé, W., van Ginneken, E.: The Netherlands: health system review. Health Syst. Transit. 12(1), xxvii, 1–228 (2010) Schäfer, W., Kroneman, M., Boerma, W., van den Berg, M., Westert, G., Devillé, W., van Ginneken, E.: The Netherlands: health system review. Health Syst. Transit. 12(1), xxvii, 1–228 (2010)
33.
go back to reference Grewal, I., Lewis, J., Flynn, T., Brown, J., Bond, J., Coast, J.: Developing attributes for a generic quality of life measure for older people: Preferences or capabilities? Soc. Sci. Med. 62(8), 1891–1901 (2006)PubMedCrossRef Grewal, I., Lewis, J., Flynn, T., Brown, J., Bond, J., Coast, J.: Developing attributes for a generic quality of life measure for older people: Preferences or capabilities? Soc. Sci. Med. 62(8), 1891–1901 (2006)PubMedCrossRef
34.
go back to reference Szende, A., Oppe, M.D.N.: EQ-5D value sets—inventory, comparative review and user guide, vol. 1. Springer, Dordrecht (2007)CrossRef Szende, A., Oppe, M.D.N.: EQ-5D value sets—inventory, comparative review and user guide, vol. 1. Springer, Dordrecht (2007)CrossRef
35.
go back to reference Lamers, L.M., McDonnell, J., Stalmeier, P.F.M., Krabbe, P.F.M., Busschbach, J.J.V.: The Dutch tariff: results and arguments for an effective design for national EQ-5D valuation studies. Health Econ. 15(10), 1121–1132 (2006)PubMedCrossRef Lamers, L.M., McDonnell, J., Stalmeier, P.F.M., Krabbe, P.F.M., Busschbach, J.J.V.: The Dutch tariff: results and arguments for an effective design for national EQ-5D valuation studies. Health Econ. 15(10), 1121–1132 (2006)PubMedCrossRef
36.
go back to reference Tan, S.S., Bouwmans, C.A., Rutten, F.F., Hakkaart-van Roijen, L.: Update of the Dutch manual for costing in economic evaluations. Int. J. Technol. Assess. Health Care 28(02), 152–158 (2012)PubMedCrossRef Tan, S.S., Bouwmans, C.A., Rutten, F.F., Hakkaart-van Roijen, L.: Update of the Dutch manual for costing in economic evaluations. Int. J. Technol. Assess. Health Care 28(02), 152–158 (2012)PubMedCrossRef
37.
go back to reference Lutomski, J.E., Baars, M.A., Kempen, J.A., Buurman, B.M., Elzen, W.P., Jansen, A.P., Kempen, G.I., Krabbe, P.F., Steunenberg, B., Steyerberg, E.W.: Validation of a frailty index from the older persons and informal caregivers survey minimum data set. J. Am. Geriatr. Soc. 61(9), 1625–1627 (2013)PubMedCrossRef Lutomski, J.E., Baars, M.A., Kempen, J.A., Buurman, B.M., Elzen, W.P., Jansen, A.P., Kempen, G.I., Krabbe, P.F., Steunenberg, B., Steyerberg, E.W.: Validation of a frailty index from the older persons and informal caregivers survey minimum data set. J. Am. Geriatr. Soc. 61(9), 1625–1627 (2013)PubMedCrossRef
38.
go back to reference Mitnitski, A.B., Mogilner, A.J., Rockwood, K.: Accumulation of deficits as a proxy measure of aging. Sci. World J. 1, 323–336 (2001)CrossRef Mitnitski, A.B., Mogilner, A.J., Rockwood, K.: Accumulation of deficits as a proxy measure of aging. Sci. World J. 1, 323–336 (2001)CrossRef
39.
go back to reference Hanmer, J., Lawrence, W.F., Anderson, J.P., Kaplan, R.M., Fryback, D.G.: Report of nationally representative values for the noninstitutionalized US adult population for 7 health-related quality-of-life scores. Med. Decis. Mak. 26(4), 391–400 (2006)CrossRef Hanmer, J., Lawrence, W.F., Anderson, J.P., Kaplan, R.M., Fryback, D.G.: Report of nationally representative values for the noninstitutionalized US adult population for 7 health-related quality-of-life scores. Med. Decis. Mak. 26(4), 391–400 (2006)CrossRef
40.
go back to reference Rodriguez-Blazquez, C., Forjaz, M.J., Prieto-Flores, M.E., Rojo-Perez, F., Fernandez-Mayoralas, G., Martinez-Martin, P.: Health status and well-being of older adults living in the community and in residential care settings: Are differences influenced by age? Aging Ment. Health 16(7), 884–891 (2012)PubMedCrossRef Rodriguez-Blazquez, C., Forjaz, M.J., Prieto-Flores, M.E., Rojo-Perez, F., Fernandez-Mayoralas, G., Martinez-Martin, P.: Health status and well-being of older adults living in the community and in residential care settings: Are differences influenced by age? Aging Ment. Health 16(7), 884–891 (2012)PubMedCrossRef
41.
go back to reference Ganiats, T.G., Miller, C.J., Kaplan, R.M.: Comparing the quality-adjusted life-year output of two treatment arms in a randomized trial. Med. Care 33(4), AS245–AS254 (1995)PubMed Ganiats, T.G., Miller, C.J., Kaplan, R.M.: Comparing the quality-adjusted life-year output of two treatment arms in a randomized trial. Med. Care 33(4), AS245–AS254 (1995)PubMed
42.
go back to reference Manca, A.A., Hawkins, N., Schulpher, M.J.: Estimating mean QALYs in trial-based cost-effectiveness analysis: the importance of controlling for baseline utility. Health Econ. 14(5), 487–496 (2005). doi:10.1002/hec.944pmid PubMedCrossRef Manca, A.A., Hawkins, N., Schulpher, M.J.: Estimating mean QALYs in trial-based cost-effectiveness analysis: the importance of controlling for baseline utility. Health Econ. 14(5), 487–496 (2005). doi:10.​1002/​hec.​944pmid PubMedCrossRef
43.
go back to reference Steiner, P.M., Cook, T.D., Shadish, W.R., Clark, M.: The importance of covariate selection in controlling for selection bias in observational studies. Psychol. Methods 15(3), 250 (2010)PubMedCrossRef Steiner, P.M., Cook, T.D., Shadish, W.R., Clark, M.: The importance of covariate selection in controlling for selection bias in observational studies. Psychol. Methods 15(3), 250 (2010)PubMedCrossRef
44.
go back to reference Nixon, R.M., Thompson, S.G.: Methods for incorporating covariate adjustment, subgroup analysis and between-centre differences into cost-effectiveness evaluations. Health Econ. 14(12), 1217–1229 (2005)PubMedCrossRef Nixon, R.M., Thompson, S.G.: Methods for incorporating covariate adjustment, subgroup analysis and between-centre differences into cost-effectiveness evaluations. Health Econ. 14(12), 1217–1229 (2005)PubMedCrossRef
45.
go back to reference Willan, A.R., Briggs, A.H.: Statistical analysis of cost-effectiveness data, vol. 37. Wiley, New York (2006)CrossRef Willan, A.R., Briggs, A.H.: Statistical analysis of cost-effectiveness data, vol. 37. Wiley, New York (2006)CrossRef
46.
go back to reference Hoch, J.S., Briggs, A.H., Willan, A.R.: Something old, something new, something borrowed, something blue: a framework for the marriage of health econometrics and cost-effectiveness analysis. Health Econ. 11(5), 415–430 (2002). doi:10.1002/hec.678 PubMedCrossRef Hoch, J.S., Briggs, A.H., Willan, A.R.: Something old, something new, something borrowed, something blue: a framework for the marriage of health econometrics and cost-effectiveness analysis. Health Econ. 11(5), 415–430 (2002). doi:10.​1002/​hec.​678 PubMedCrossRef
47.
go back to reference Gomes, M., Grieve, R., Nixon, R., Ng, E.S.W., Carpenter, J., Thompson, S.G.: Methods for covariate adjustment in cost-effectiveness analysis that use cluster randomised trials. Health Econ. 21(9), 1101–1118 (2012)PubMedCrossRef Gomes, M., Grieve, R., Nixon, R., Ng, E.S.W., Carpenter, J., Thompson, S.G.: Methods for covariate adjustment in cost-effectiveness analysis that use cluster randomised trials. Health Econ. 21(9), 1101–1118 (2012)PubMedCrossRef
48.
go back to reference Pocock, S.J., Assmann, S.E., Enos, L.E., Kasten, L.E.: Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems. Stat. Med. 21(19), 2917–2930 (2002)PubMedCrossRef Pocock, S.J., Assmann, S.E., Enos, L.E., Kasten, L.E.: Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems. Stat. Med. 21(19), 2917–2930 (2002)PubMedCrossRef
49.
go back to reference Raghunathan, T.E., Lepkowski, J.M., Van Hoewyk, J., Solenberger, P.: A multivariate technique for multiply imputing missing values using a sequence of regression models. Surv. Methodol. 27(1), 85–96 (2001) Raghunathan, T.E., Lepkowski, J.M., Van Hoewyk, J., Solenberger, P.: A multivariate technique for multiply imputing missing values using a sequence of regression models. Surv. Methodol. 27(1), 85–96 (2001)
51.
go back to reference Little, R.J.A., Rubin, D.B.: Statistical analysis with missing data. Wiley, New York (1987) Little, R.J.A., Rubin, D.B.: Statistical analysis with missing data. Wiley, New York (1987)
52.
go back to reference Gomes, M., Ng, E.S.-W., Grieve, R., Nixon, R., Carpenter, J., Thompson, S.G.: Developing appropriate methods for cost-effectiveness analysis of cluster randomized trials. Med. Decis. Mak. 32(2), 350–361 (2012)CrossRef Gomes, M., Ng, E.S.-W., Grieve, R., Nixon, R., Carpenter, J., Thompson, S.G.: Developing appropriate methods for cost-effectiveness analysis of cluster randomized trials. Med. Decis. Mak. 32(2), 350–361 (2012)CrossRef
53.
go back to reference Campbell, M.K., Piaggio, G., Elbourne, D.R., Altman, D.G.: Consort 2010 statement: extension to cluster randomised trials. BMJ. 345, e5661 (2012)PubMedCrossRef Campbell, M.K., Piaggio, G., Elbourne, D.R., Altman, D.G.: Consort 2010 statement: extension to cluster randomised trials. BMJ. 345, e5661 (2012)PubMedCrossRef
54.
go back to reference Manca, A., Rice, N., Sculpher, M.J., Briggs, A.H.: Assessing generalisability by location in trial-based cost-effectiveness analysis: the use of multilevel models. Health Econ. 14(5), 471–485 (2005)PubMedCrossRef Manca, A., Rice, N., Sculpher, M.J., Briggs, A.H.: Assessing generalisability by location in trial-based cost-effectiveness analysis: the use of multilevel models. Health Econ. 14(5), 471–485 (2005)PubMedCrossRef
55.
go back to reference Bachmann, M.O., Fairall, L., Clark, A., Mugford, M.: Methods for analyzing cost effectiveness data from cluster randomized trials. Cost Eff. Resour. Alloc. 5(1), 12 (2007)PubMedCentralPubMedCrossRef Bachmann, M.O., Fairall, L., Clark, A., Mugford, M.: Methods for analyzing cost effectiveness data from cluster randomized trials. Cost Eff. Resour. Alloc. 5(1), 12 (2007)PubMedCentralPubMedCrossRef
56.
go back to reference Fenwick, E., O’Brien, B.J., Briggs, A.: Cost-effectiveness acceptability curves—facts, fallacies and frequently asked questions. Health Econ. 13(5), 405–415 (2004)PubMedCrossRef Fenwick, E., O’Brien, B.J., Briggs, A.: Cost-effectiveness acceptability curves—facts, fallacies and frequently asked questions. Health Econ. 13(5), 405–415 (2004)PubMedCrossRef
57.
go back to reference Hoch, J.S., Rockx, M.A., Krahn, A.D.: Using the net benefit regression framework to construct cost-effectiveness acceptability curves: an example using data from a trial of external loop recorders versus Holter monitoring for ambulatory monitoring of. BMC Health Serv. Res. 6(1), 68 (2006)PubMedCentralPubMedCrossRef Hoch, J.S., Rockx, M.A., Krahn, A.D.: Using the net benefit regression framework to construct cost-effectiveness acceptability curves: an example using data from a trial of external loop recorders versus Holter monitoring for ambulatory monitoring of. BMC Health Serv. Res. 6(1), 68 (2006)PubMedCentralPubMedCrossRef
58.
go back to reference Leyrat, C., Caille, A., Donner, A., Giraudeau, B.: Propensity scores used for analysis of cluster randomized trials with selection bias: a simulation study. Stat. Med. 32, 3357–3372 (2013). doi:10.1002/sim.5795 PubMedCrossRef Leyrat, C., Caille, A., Donner, A., Giraudeau, B.: Propensity scores used for analysis of cluster randomized trials with selection bias: a simulation study. Stat. Med. 32, 3357–3372 (2013). doi:10.​1002/​sim.​5795 PubMedCrossRef
59.
go back to reference Sumukadas, D., Witham, M.D., Struthers, A.D., McMurdo, M.E.: Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. Can. Med. Assoc. J. 177(8), 867–874 (2007)CrossRef Sumukadas, D., Witham, M.D., Struthers, A.D., McMurdo, M.E.: Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. Can. Med. Assoc. J. 177(8), 867–874 (2007)CrossRef
60.
go back to reference Walter, S.D., Forbes, A., Chan, S., Macaskill, P., Irwig, L.: When should one adjust for measurement error in baseline variables in observational studies? Biom. J. 53(1), 28–39 (2011)PubMedCrossRef Walter, S.D., Forbes, A., Chan, S., Macaskill, P., Irwig, L.: When should one adjust for measurement error in baseline variables in observational studies? Biom. J. 53(1), 28–39 (2011)PubMedCrossRef
61.
62.
go back to reference Gobbens, R., Luijkx, K., Wijnen-Sponselee, M., Schols, J.: Towards an integral conceptual model of frailty. J. Nutr. Health Aging 14(3), 175–181 (2010)PubMedCrossRef Gobbens, R., Luijkx, K., Wijnen-Sponselee, M., Schols, J.: Towards an integral conceptual model of frailty. J. Nutr. Health Aging 14(3), 175–181 (2010)PubMedCrossRef
63.
go back to reference Norman, G.R., Sloan, J.A., Wyrwich, K.W.: Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med. Care 41(5), 582–592 (2003)PubMed Norman, G.R., Sloan, J.A., Wyrwich, K.W.: Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med. Care 41(5), 582–592 (2003)PubMed
64.
go back to reference Kodner, D.L.: Consumer-directed services: lessons and implications for integrated systems of care. Int. J. Integr. Care 3, e12 (2003)PubMed Kodner, D.L.: Consumer-directed services: lessons and implications for integrated systems of care. Int. J. Integr. Care 3, e12 (2003)PubMed
65.
go back to reference Mur-Veeman, I., Eijkelberg, I., Spreeuwenberg, C.: How to manage the implementation of shared care—a discussion of the role of power, culture and structure in the development of shared care arrangements. J. Manag. Med. 15(2), 142–155 (2001)PubMedCrossRef Mur-Veeman, I., Eijkelberg, I., Spreeuwenberg, C.: How to manage the implementation of shared care—a discussion of the role of power, culture and structure in the development of shared care arrangements. J. Manag. Med. 15(2), 142–155 (2001)PubMedCrossRef
66.
go back to reference Jones, D.A., Victor, C.R., Vetter, N.J.: The problem of loneliness in the elderly in the community: characteristics of those who are lonely and the factors related to loneliness. J. R. Coll. Gen. Pract 35(272), 136 (1985)PubMedCentralPubMed Jones, D.A., Victor, C.R., Vetter, N.J.: The problem of loneliness in the elderly in the community: characteristics of those who are lonely and the factors related to loneliness. J. R. Coll. Gen. Pract 35(272), 136 (1985)PubMedCentralPubMed
69.
go back to reference Meeuwsen, E.J., Melis, R., Adang, E., Golüke-Willemse, G., Krabbe, P., De Leest, B., Van Raak, F., Schölzel-Dorenbos, C., Visser, M., Wolfs, C.: Cost-effectiveness of post-diagnosis treatment in dementia coordinated by multidisciplinary memory clinics in comparison to treatment coordinated by general practitioners: an example of a pragmatic trial. J. Nutr. Health Aging (JNHA) 13(3), 242–248 (2009)CrossRef Meeuwsen, E.J., Melis, R., Adang, E., Golüke-Willemse, G., Krabbe, P., De Leest, B., Van Raak, F., Schölzel-Dorenbos, C., Visser, M., Wolfs, C.: Cost-effectiveness of post-diagnosis treatment in dementia coordinated by multidisciplinary memory clinics in comparison to treatment coordinated by general practitioners: an example of a pragmatic trial. J. Nutr. Health Aging (JNHA) 13(3), 242–248 (2009)CrossRef
70.
go back to reference Graff, M.J., Vernooij-Dassen, M.J., Thijssen, M., Dekker, J., Hoefnagels, W.H., Rikkert, M.G.O.: Community based occupational therapy for patients with dementia and their care givers: randomised controlled trial. Br. Med. J. (BMJ) 333(7580), 1196 (2006)CrossRef Graff, M.J., Vernooij-Dassen, M.J., Thijssen, M., Dekker, J., Hoefnagels, W.H., Rikkert, M.G.O.: Community based occupational therapy for patients with dementia and their care givers: randomised controlled trial. Br. Med. J. (BMJ) 333(7580), 1196 (2006)CrossRef
Metadata
Title
Cost-effectiveness of integrated care in frail elderly using the ICECAP-O and EQ-5D: does choice of instrument matter?
Authors
Peter Makai
Willemijn Looman
Eddy Adang
René Melis
Elly Stolk
Isabelle Fabbricotti
Publication date
01-05-2015
Publisher
Springer Berlin Heidelberg
Published in
The European Journal of Health Economics / Issue 4/2015
Print ISSN: 1618-7598
Electronic ISSN: 1618-7601
DOI
https://doi.org/10.1007/s10198-014-0583-7

Other articles of this Issue 4/2015

The European Journal of Health Economics 4/2015 Go to the issue