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Modern Rheumatology
Published in: Modern Rheumatology 1/2010

01-02-2010 | Case Report

Cutaneous vasculitis induced by TNF inhibitors: a report of three cases

Authors: Keita Fujikawa, Atsushi Kawakami, Tomayoshi Hayashi, Naoki Iwamoto, Shin-ya Kawashiri, Toshiyuki Aramaki, Kunihiro Ichinose, Mami Tamai, Kazuhiko Arima, Makoto Kamachi, Satoshi Yamasaki, Hideki Nakamura, Hiroaki Ida, Tomoki Origuchi, Katsumi Eguchi

Published in: Modern Rheumatology | Issue 1/2010

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Abstract

We describe 3 rheumatoid arthritis (RA) patients with anti-tumor necrosis factor (TNF) therapy-induced cutaneous vasculitis. Two cases were induced by infliximab and the other, in whom cutaneous vasculitis was found early at the start of therapy, was induced by etanercept. Skin biopsy was obtained in 2 patients, with histology-proven leukocytoclastic vasculitis. One patient spontaneously improved after cessation of the TNF inhibitor. Two patients required oral corticosteroid, the efficacy of which was observed to be excellent and rapid.
Literature
1.
Kubo S, Yamaoka K, Saito K, Nakano K, Sawamukai N, Nawata M, et al. Six cases of non-rheumatoid vasculitis observed during TNF inhibitors therapy in rheumatoid arthritis. Mod Rheumatol Suppl. 2009;10:S120.
2.
Arnett EC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatology Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–24.CrossRefPubMed
3.
Jarrett SJ, Cunnane G, Conaghan PG, et al. Anti-tumor necrosis factor-alpha therapy-induced vasculitis: case series. J Rheumatol. 2003;30(10):2287–91.PubMed
4.
Flendrie M, Vissers WH, Creemers MC, et al. Dermatological conditions during TNF-alpha-blocking therapy in patients with rheumatoid arthritis: a prospective study. Arthritis Res Ther. 2005;7(3):R666–76.CrossRefPubMed
5.
Ramos-Casals M, Brito-Zerón P, Muñoz S, et al. Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases. Medicine (Baltimore). 2007;86(4):242–51.CrossRef
6.
Guillevin L, Mouthon L. Tumor necrosis factor-alpha blockade and the risk of vasculitis. J Rheumatol. 2004;31(10):1885–7.PubMed
Metadata
Title
Cutaneous vasculitis induced by TNF inhibitors: a report of three cases
Authors
Keita Fujikawa
Atsushi Kawakami
Tomayoshi Hayashi
Naoki Iwamoto
Shin-ya Kawashiri
Toshiyuki Aramaki
Kunihiro Ichinose
Mami Tamai
Kazuhiko Arima
Makoto Kamachi
Satoshi Yamasaki
Hideki Nakamura
Hiroaki Ida
Tomoki Origuchi
Katsumi Eguchi
Publication date
01-02-2010
Publisher
Springer Japan
Published in
Modern Rheumatology / Issue 1/2010
Print ISSN: 1439-7595
Electronic ISSN: 1439-7609
DOI
https://doi.org/10.1007/s10165-009-0232-7

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