Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Modern Rheumatology
Published in: Modern Rheumatology 4/2006

Open Access 01-08-2006 | REVIEW ARTICLE

Cartilage destruction by matrix degradation products

Author: Tadashi Yasuda

Published in: Modern Rheumatology | Issue 4/2006

Login to get access

Abstract

The progressive destruction of articular cartilage is one of the hallmarks of osteoarthritis and rheumatoid arthritis. Cartilage degradation is attributed to different classes of catabolic factors, including proinflammatory cytokines, aggrecanases, matrix metalloproteinases, and nitric oxide. Recently, matrix degradation products generated by excessive proteolysis in arthritis have been found to mediate cartilage destruction. These proteolytic fragments activate chondrocytes and synovial fibroblasts via specific cell surface receptors that can stimulate catabolic intracellular signaling pathways, leading to the induction of such catalysts. This review describes the catabolic activities of matrix degradation products, especially fibronectin fragments, and discusses the pathologic implication in cartilage destruction in osteoarthritis and rheumatoid arthritis. Increased levels of these degradation products, found in diseased joints, may stimulate cartilage breakdown by mechanisms of the kind demonstrated in the review.
Literature
1.
Poole, AR 2001Cartilage in health and diseaseKoopman, WJ eds. Arthritis and allied conditions: a textbook of rheumatology, 14th ed. vol 1Lippincott, Williams and WilkinsBaltimore22684
2.
3.
Kempson, GE, Muir, H, Pollard, C, Tuke, M 1973The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycansBiochim Biophys Acta29745672PubMed
4.
Mow VC, Setton LA, Ratcliffe DS, Howell DS, Buckwalter JA. Structure-function relationships of articular cartilage and the effects of joint instability and trauma on cartilage function. In: Brandt KD, editor. Cartilage changes in osteoarthritis. Indiana School of Medicine/CibaGeigy; 1990. 22–42
5.
Carney, SL, Billingham, MEJ, Muir, H, Sandy, JD 1984Demonstration of increased proteoglycan turnover in cartilage explants from dogs with experimental osteoarthritisJ Orthop Res22016PubMedCrossRef
6.
McDevitt, CA, Muir, H 1976Biochemical changes in the cartilage of the knee in experimental and natural osteoarthritis in the dogJ Bone Joint Surg [Br]5894101
7.
Bonassar, LJ, Frank, EH, Murray, JC, Paguio, CG, Moore, VL, Lark, MW,  et al. 1995Changes in cartilage composition and physical properties due to stromelysin degradationArthritis Rheum3817383PubMedCrossRef
8.
Kempson, GE 1979Mechanical properties of articular cartilageFreeman, MAR eds. Adult articular cartilagePitman MedicalTunbridge Wells333414
9.
Dodge, G, Poole, AR 1989Immunohistochemical detection and immunohistochemical analysis of type II collagen degradation in human normal, rheumatoid and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin-1J Clin Invest8364761PubMedCrossRef
10.
Hollander, AP, Pidoux, I, Reiner, A, Rorabeck, C, Bourne, R, Poole, AR 1994Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassayJ Clin Invest93172232PubMedCrossRef
11.
Arend, WP, Dayer, JM 1995Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritisArthritis Rheum3815160PubMedCrossRef
12.
Burton-Wurster, N, Butler, M, Harter, S, Colombo, C, Quintavalla, J, Swartzendurber, D,  et al. 1986Presence of fibronectin in articular cartilage in two animal models of osteoarthritisJ Rheumatol1317582PubMed
13.
Lavietes, BB, Carsons, S, Diamond, HS, Laskin, RS 1985Synthesis, secretion, and deposition of fibronectin in cultured human synoviumArthritis Rheum28101626PubMedCrossRef
14.
Hynes, RO 1990FibronectinsSpringerBerlin Heidelberg New York
15.
Schwarzbauer, JE 1991Alternative splicing of fibronectin: three variants, three functionsBioEssays1352733PubMedCrossRef
16.
17.
Yamada, KM 1991Adhesive recognition sequencesJ Biol Chem2661280912PubMed
18.
McCarthy, JB, Chelberg, MK, Mickelson, DJ, Furcht, LT 1988Localization and chemical synthesis of fibronectin peptides with melanoma adhesion and heparin binding activitiesBiochemistry2713808PubMedCrossRef
19.
Drake, SL, Klein, DJ, Mickelson, DJ, Oegema, TR, Furcht, LT, McCarthy, JB 1992Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptideJ Cell Biol117133141PubMedCrossRef
20.
Iida, J, Skubitz, AP, Furcht, LT, Wayner, EW, McCarthy, JB 1992Coordinate role for cell surface chondroitin sulfate proteoglycan and α4β1 in mediating melanoma cell adhesion to fibronectinJ Cell Biol11843144PubMedCrossRef
21.
Lories, V, Cassiman, JJ, van der Berghe, H, David, G 1992Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cell and fibroblastsJ Biol Chem267111622PubMed
22.
Woods, A, McCarthy, JB, Furcht, LT, Couchman, JR 1993A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formationMol Biol Cell460513PubMed
23.
Giuseppetti, JM, McCarthy, JB, Letourneau, PC 1994Isolation and partial characterization of a cell-surface heparan sulfate proteoglycan from embryonic rat spinal cordJ Neurosci Res3758495PubMedCrossRef
24.
Wayner, EA, Garcia-Pardo, A, Humphries, MJ, McDonald, JA, Carter, WG 1989Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectinJ Cell Biol109132130PubMedCrossRef
25.
Guan, J-L, Hynes, RO 1990Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1 Cell605361PubMedCrossRef
26.
Mould, AP, Humphries, MJ 1991Identification of a novel recognition sequence for the α4β1 in the COOH-terminal heparin-binding domain of fibronectinEMBO J10408995PubMed
27.
Mould, AP, Wheldon, LA, Koriyama, A, Wayner, EA, Yamada, KM, Humphries, MJ 1990Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin recognized by the integrin α4β1J Biol Chem26540204PubMed
28.
Mould, AP, Koriyama, A, Yamada, KM, Humphries, MJ 1991The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin α4β1J Biol Chem266357985PubMed
29.
Miller, DR, Mankin, HJ, Shoji, H, D’Ambrosia, RD 1984Identification of fibronectin in preparations of osteoarthritic human cartilageConnect Tissue Res1226775PubMedCrossRef
30.
Jones, KL, Brown, M, Ali, SY, Brown, RA 1987An immunohistochemical study of fibronectin in human osteoarthritic and disease-free articular cartilageAnn Rheum Dis4680915PubMedCrossRef
31.
Homandberg, GA, Wen, C, Hui, F 1998Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluidOsteoarthritis Cartilage623144PubMedCrossRef
32.
Xie, DL, Meyers, R, Homandberg, GA 1992Fibronectin fragments in osteoarthritic synovial fluidJ Rheumatol19144852PubMed
33.
Scott, DL, Delamare, JP, Walton, KW 1981The distribution of fibronectin in the pannus in rheumatoid arthritisBr J Exp Pathol6236268PubMed
34.
Shiozawa, S, Ziff, M 1983Immunoelectron microscopic demonstration of fibronectin in rheumatoid pannus and at the cartilage-pannus junctionAnn Rheum Dis4225463PubMedCrossRef
35.
Xie, DL, Homandberg, GA 1993Fibronectin fragments bind to and penetrate cartilage tissue resulting in proteinase expression and cartilage damageBiochim Biophys Acta118218996PubMed
36.
Homandberg, GA, Meyers, R, Xie, DL 1992Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in cultureJ Biol Chem2673597604PubMed
37.
Yasuda, T, Poole, AR 2002A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathwayArthritis Rheum4613848PubMedCrossRef
38.
Homandberg, GA, Meyers, R, Williams, JM 1993Intraarticular injection of fibronectin fragments causes severe depletion of cartilage proteoglycans in vivoJ Rheumatol20137882PubMed
39.
Xie, DL, Hui, F, Homandberg, GA 1993Fibronectin fragments alter matrix protein synthesis in cartilage tissue cultured in vitroArch Biochem Biophys3071108PubMedCrossRef
40.
Abbaszade, I, Liu, RQ, Yang, F, Rosenfeld, SA, Ross, OH, Link, JR,  et al. 1999Cloning and characterization of ADAMTS11, an aggrecanase from ADAMTS familyJ Biol Chem2742344350PubMedCrossRef
41.
Tortorella, MD, Burn, TC, Pratta, MA, Abbaszade, I, Hollos, JM, Liu, R,  et al. 1999Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteinsScience28416646PubMedCrossRef
42.
Fosang, AJ 1999Aggrecanase and cartilage proteoglycan degradationBradshaw, DNixon, JSBottomley, K eds. Metalloproteinases as targets for anti-inflammatory drugsBirkhauserBasel11743
43.
Singer, II, Scott, S, Kawka, DW, Bayne, EK, Weidner, JR, Williams, HR,  et al. 1997Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid jointsJ Clin Invest10093106PubMedCrossRef
44.
Stanton, H, Ung, L, Fosang, AJ 2002The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanasesBiochem J36418190PubMed
45.
Homandberg, GA, Davis, G, Maniglia, C, Shrikhande, A 1997Cartilage chondrolysis by fibronectin fragments causes cleavage of aggrecan at the same site as found in osteoarthritic cartilageOsteoarthritis Cartilage54503PubMedCrossRef
46.
47.
Jeffery, J 1998Interstitial collagenasesParks, WCMecham, RP eds. Matrix metalloproteinasesAcademic PressSan Diego1538CrossRef
48.
Freije, JM, Diez-Itza, I, Balbín, B, Sanchez, LM, Blasco, R, Tolivia, J,  et al. 1994Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomasJ Biol Chem2691676673PubMed
49.
Knäuper, V, Cowell, S, Smith, B, López-Otín, C, O’Shea, M, Morris, H,  et al. 1997The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interactionJ Biol Chem272760816PubMedCrossRef
50.
Krane, SM, Byrne, MH, Lemaitre, V, Henriet, P, Jeffrey, JJ, Witter, JP,  et al. 1996Different collagenase gene products have different roles in degradation of type I collagenJ Biol Chem2712850915PubMedCrossRef
51.
Fosang, AJ, Last, K, Knäuper, V, Murphy, G, Neame, PJ 1996Degradation of cartilage aggrecan by collagenase-3 (MMP-13)FEBS Lett3801720PubMedCrossRef
52.
Knäuper, V, López-Otín, C, Smith, B, Knight, G, Murphy, G 1996Biochemical characterization of human collagenase-3J Biol Chem271154450PubMedCrossRef
53.
Stahle-Backdahl, M, Sandstedt, B, Bruce, K, Lindahl, A, Jiménez, MG, Vega, JA,  et al. 1997Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritisLab Invest7671728PubMed
54.
Johansson, N, Saarialho-Kere, U, Airola, K, Herva, R, Nissinen, L, Westermarck, J,  et al. 1997collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone developmentDev Dyn20838797PubMedCrossRef
55.
Billinghurst, RC, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C,  et al. 1997Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilageJ Clin Invest99153445PubMedCrossRef
56.
Lindy, O, Konttinen, YT, Sorsa, T, Ding, Y, Santavirta, S, Ceponis, A 1997Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synoviumArthritis Rheum4013919PubMedCrossRef
57.
Balbín, M, Pendás, AM, Uría, JA, Jiménez, MG, Freije, JP, López-Otín, C 1999Expression and regulation of collagenase-3 (MMP-13) in human malignant tumorsAPMIS1074553PubMedCrossRef
58.
Werb, Z, Tremble, PM, Behrendtsen, O, Crowley, E, Damsky, CH 1989Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expressionJ Cell Biol10987789PubMedCrossRef
59.
Forsyth, CB, Pulai, J, Loeser, RF 2002Fibronectin fragments and blocking antibodies to α2β1 and α5β1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytesArthritis Rheum46236876PubMedCrossRef
60.
Xie, D-L, Hui, F, Meyers, R, Homandberg, GA 1994Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysisArch Biochem Biophys31120512PubMedCrossRef
61.
Yasuda, T, Poole, AR, Shimizu, M, Nakagawa, T, Julovi, SM, Tamamura, H,  et al. 2003Involvement of CD44 in induction of matrix metalloproteinases by a carboxyl-terminal heparin-binding fragment of fibronectin in human articular cartilage in cultureArthritis Rheum48127180PubMedCrossRef
62.
Yasuda, T, Shimizu, M, Nakagawa, T, Julovi, SM, Nakamura, T 2003Matrix metalloproteinase production by COOH-terminal heparin-binding fibronectin fragment in rheumatoid synovial cellsLab Invest8315362PubMed
63.
64.
Nathan, C 1992Nitric oxide as a secretory product of mammalian cellsFASEB J6305164PubMed
65.
Stadler, J, Stefanovic-Racic, M, Billiar, TR, Curran, RD, McIntyre, LA, Georgescu, HI,  et al. 1991Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharideJ Immunol147391520PubMed
66.
Sakurai, H, Kohsaka, H, Liu, MF, Higashiyama, H, Hirata, Y, Kanno, K,  et al. 1995Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritidesJ Clin Invest96235763PubMedCrossRef
67.
Ialenti, A, Moncada, S, Di Rosa, M 1993Modulation of adjuvant arthritis by endogenous nitric oxideBr J Pharmacol1107016PubMed
68.
McCartney-Francis, N, Allen, JB, Mizel, DE, Albina, JE, Xie, QW, Nathan, CF,  et al. 1993Suppression of arthritis by an inhibitor of nitric oxide synthaseJ Exp Med17874954PubMedCrossRef
69.
Gemba, T, Valbracht, J, Alsalameh, S, Lotz, M 2002Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragmentJ Biol Chem27790711PubMedCrossRef
70.
Yasuda, T, Kakinuma, T, Julovi, SM, Yoshida, M, Hiramitsu, T, Akiyoshi, M,  et al. 2004COOH-terminal heparin-binding fibronectin fragment induces nitric oxide production in rheumatoid cartilage through CD44Rheumatology (Oxford)43111620CrossRef
71.
Homandberg, GA, Hui, F, Wen, C 1996Association of proteoglycan degradation with catabolic cytokine and stromelysin release from cartilage cultured with fibronectin fragmentsArch Biochem Biophys33432531PubMedCrossRef
72.
Homandberg, GA, Hui, F, Wen, C, Purple, C, Bewsey, K, Koepp, H,  et al. 1997Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokinesBiochem. J3217517PubMed
73.
Bewsey, KE, Wen, C, Purple, C, Homandberg, GA 1996Fibronectin fragments induce the expression of stromelysin-1 mRNA and protein in bovine chondrocytes in monolayer cultureBiochim Biophys Acta13175564PubMed
74.
Arner, EC, Tortorella, MD 1995Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1Arthritis Rheum38130414PubMedCrossRef
75.
Johansson, S, Svineng, G, Wennerberg, K, Armulik, A, Lohikangas, L 1997Fibronectin-integrin interactionsFront Biosci2D12646PubMed
76.
77.
Giancotti, FG, Mainiero, F 1994Integrin-mediated adhesion and signaling in tumorigenesisBiochem Biophys Acta11984764PubMed
78.
Clark, EA, Brugge, JS 1995Integrins and signal transduction pathway: the road takenScience2682339PubMedCrossRef
79.
Schwarz, MA, Scaller, MD, Ginsberg, MH 1995Integrins: emerging paradigms of signal transductionAnnu Rev Cell Dev Biol1154999CrossRef
80.
81.
Yamada, KM, Miyamoto, S 1995Integrin transmembrane signaling and cytoskeletal controlCurr Opin Cell Biol76819PubMedCrossRef
82.
Giancotti, FG 1997Integrin signaling: specificity and cell cycle progressionCurr Opin Cell Biol9691700PubMedCrossRef
83.
Zhang, Z, Vuori, K, Reed, JC, Ruoslahti, E 1995The α5β1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expressionProc Natl Soc Sci USA9261615CrossRef
84.
Sastry, SK, Lakonishok, M, Thomas, DA, Muschler, J, Horwitz, AF 1996Integrin α subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiationJ Cell Biol13316984PubMedCrossRef
85.
Yamada, KM 1991Adhesive recognition sequencesJ Biol Chem2661280912PubMed
86.
Damsky, CH, Werb, Z 1992Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular informationCurr Opin Cell Biol477281PubMedCrossRef
87.
Homandberg, GA, Costa, V, Ummadi, V, Pichika, R 2002Antisense oligonucleotides to the integrin receptor subunit alpha5 decrease fibronectin fragment mediated cartilage chondrolysisOsteoarthritis Cartilage1038193PubMedCrossRef
88.
Homandberg, GA, Costa, V, Wen, C 2002Fibronectin fragments active in chondrocytic chondrolysis can be chemically cross-linked to the alpha5 integrin receptor subunitOsteoarthritis Cartilage1093849PubMedCrossRef
89.
Dzamba, BJ, Bultmann, H, Akiyama, SK, Peters, DM 1994Substrate-specific binding of the amino terminus of fibronectin to an integrin complex in focal adhesionsJ Biol Chem2691964652PubMed
90.
McKeown-Longo, PJ, Mosher, DF 1985Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblastsJ Cell Biol10036474PubMedCrossRef
91.
Quade, BJ, McDonald, JA 1988Fibronectin’s amino-terminal matrix assembly site is located within the 29-kDa amino-terminal domain containing five type I repeatsJ Biol Chem263196029PubMed
92.
Schwarzbauer, JE 1991Identification of the fibronectin sequences required for assembly of a fibrillar matrixJ Cell Biol113146373PubMedCrossRef
93.
Sottile, J, Schwarzbauer, J, Selegue, J, Mosher, DF 1991Five type I modules of fibronectin form a functional unit that binds to fibroblasts and Staphylococcus aureus J Biol Chem266128403PubMed
94.
Ishikawa, H, Hirata, S, Nishibayashi, Y, Imura, S, Kubo, H, Ohno, O 1994The role of adhesion molecules in synovial pannus formation in rheumatoid arthritisClin Orthop300297303PubMed
95.
Wayner, EA, Garcia-Pardo, A, Humphries, MJ, McDonald, A, Carter, WG 1989Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectinJ Cell Biol109132130PubMedCrossRef
96.
Guan, J-L, Hynes, RO 1990Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1Cell605361PubMedCrossRef
97.
Lapadula, G, Iannoue, F, Zuccaro, C, Grattgliano, V, Covell, M, Patella, V,  et al. 1997Integrin expression on chondrocytes: Correlations with the degree of cartilage damage in human osteoarthritisClin Exp Rheum1524754
98.
Ostergaard, K, Salter, M, Petersen, J, Bendtzen, K, Hvalris, J, Andersen, CB 1998Expression of α and β subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral headsAnn Rheum Dis573038PubMedCrossRef
99.
Aruffo, A, Stamenkovic, I, Melnick, M, Underhill, CB, Seed, B 1990CD44 is the principal cell surface receptor for hyaluronateCell61130313PubMedCrossRef
100.
Screaton, GR, Bell, MV, Jackson, DG, Cornelis, FB, Gerth, U, Bell, JI 1992Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exonsProc Natl Acad Sci USA89121604PubMedCrossRef
101.
Salter, DM, Godolphin, JL, Gourlay, MS, Lawson, MF, Hughs, DE, Dunne, E 1996Analysis of human articular chondrocyte CD44 isoform expression and function in health and diseaseJ Pathol179396402PubMedCrossRef
102.
Lesley, J, Hyman, R 1998CD44 structure and functionFront Biosci3D61630PubMed
103.
Bennet, KL, Jackson, DG, Simon, JC, Tanczos, E, Peach, R, Modrell, B,  et al. 1995CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factorJ Cell Biol12868798CrossRef
104.
Jalkanen, S, Jalkanen, M 1992Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectinJ Cell Biol11681725PubMedCrossRef
105.
Barkalow, FJ, Schwarzbauer, JE 1994Interactions between fibronectin and chondroitin sulfate are modulated by molecular contextJ Biol Chem269395762PubMed
106.
Woods, A, McCarthy, JB, Furcht, LT, Couchman, JR 1993A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formationMol Biol Cell460513PubMed
107.
Ostergaard, K, Salter, DM, Andersen, CB, Petersen, J, Bendtzen, K 1997CD44 expression is up-regulated in the deep zone of osteoarthritic cartilage from human femoral headsHistopathology314519PubMedCrossRef
108.
Takagi, T, Okamoto, R, Suzuki, K, Hayashi, T, Sato, M, Sato, M,  et al. 2001Up-regulation of CD44 in rheumatoid chondrocytesScand J Rheumatol301103PubMedCrossRef
109.
Chow, G, Knudson, CB, Homandberg, G, Knudson, W 1995Increased expression of CD44 in bovine articular chondrocytes by catabolic cellular mediatorsJ Biol Chem2702773441PubMedCrossRef
110.
Hauselmann, HJ, Aydelotte, MB, Schumacher, BL, Kuettner, KE, Gitelis, SH, Thonar, EJ 1992Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beadsMatrix1211629PubMed
111.
Rutter, JL, Benbow, U, Coon, CI, Brinckerhoff, CE 1997Cell-type specific regulation of human interstitial collagense-1 gene expression by interleukin-1β (IL-1β) in human fibroblasts and BC-8701 breast cancer cellsJ Cell Biochem6632236PubMedCrossRef
112.
Pendas, AM, Balbin, M, Llano, E, Jimenez, MG, Lopez-Otin, C 1997Structural analysis and promoter characterization of human collagenase-3 gene (MMP-13)Genomics4022233PubMedCrossRef
113.
114.
Segar, R, Krebs, EG 1995The MAPK signaling cascadeFASEB J972635
115.
Garrington, TP, Johnston, GL 1999Organization and regulation of mitogen-activated protein kinase signaling pathwaysCurr Opin Cell Biol112118PubMedCrossRef
116.
Yasuda, T, Julovi, SM, Hiramitsu, T, Yoshida, M, Nakamura, T 2004Requirement of mitogen-activated protein kinase for collagenase production by the fibronectin fragment in human articular chondrocytes in cultureMod Rheumatol145460PubMedCrossRef
117.
Mainiero, F, Gismondi, A, Soriani, A, Cippitelli, M, Palmieri, G, Jacobelli, J,  et al. 1998Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cellsJ Exp Med188126775PubMedCrossRef
118.
Chen, Q, Kinch, MS, Lin, TH, Burridge, K, Juliano, RL 1994Integrin-mediated cell adhesion activates mitogen-activated protein kinasesJ Biol Chem269266025PubMed
119.
Vincenti, MP, Coon, CI, Brinckerhoff, CE 19981998. Nuclear factor κB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β-stimulated synovial fibroblastsArthritis Rheum41198794PubMedCrossRef
120.
Mengshol, JA, Vincenti, MP, Coon, CI, Barchowsky, A, Brinckerhoff, CE 2000Interleukin-1 induction of collagenase-3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor κB: differential regulation of collagenase 1 and collagenase 3Arthritis Rheum43801811PubMedCrossRef
121.
Baldwin, ASJ 1996The NF-κB and IκB proteins: new discoveries and insightsAnn Rev Immunol1464983CrossRef
122.
Biswas, C, Dayer, JM 1979Stimulation of collagenase production by collagen in mammalian cell culturesCell18103541PubMedCrossRef
123.
Dayer, JM, Trentham, DE, David, JR, Krane, SM 1980Collagens stimulate the production of mononuclear cell factor (MCF) and prostaglandins (PGE2) by human monocytesTrans Assoc Am Phys9332635PubMed
124.
Dayer, JM, Trentham, DE, Krane, SM 1982Collagens act as ligands to stimulate human monocytes to produce mononuclear cell factor (MCF) and prostaglandins (PGE2)Collagen Rel Res252340
125.
Jeng, KG, Liu, M, Lan, J, Wu, C, Wong, DW, Cheung, BM 1995Collagen induces cytokine production by synovial fluid mononuclear cells in rheumatoid arthritisImmunol Lett45137PubMedCrossRef
126.
Goto, M, Yoshinoya, S, Miyamoto, T, Sasano, M, Okamoto, M, Nishioka, K,  et al. 1988Stimulation of interleukin-1α and interleukin-1β release from human monocytes by cyanogen bromide peptides of type II collagenArthritis Rheum31150814PubMedCrossRef
127.
Jennings, L, Wu, L, King, KB, Hammerle, H, Cs-Szabo, G, Mollenauer, J 2001The effects of collagen fragments on the extracellular metabolism of bovine and human chondrocytesConnect Tiss Res427186CrossRef
128.
Yasuda T, Mwale F, Burgess J, Poole AR. Type II collagen fragments alter type II and IX collagen turnover in bovine articular chondrocyte culture. Orthopaed Trans 1999;336
129.
Knudson, W, Casey, B, Nishida, Y, Eger, W, Kuettner, KE, Knudson, CB 2000Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysisArthritis Rheum43116574PubMedCrossRef
130.
Iacob, S, Knudson, CB 2006Hyaluronan fragments activate nitric oxide synthase and the production of nitric oxide by articular chondrocytesInt J Biochem Cell Biol3812333PubMedCrossRef
Metadata
Title
Cartilage destruction by matrix degradation products
Author
Tadashi Yasuda
Publication date
01-08-2006
Publisher
Springer-Verlag
Published in
Modern Rheumatology / Issue 4/2006
Print ISSN: 1439-7595
Electronic ISSN: 1439-7609
DOI
https://doi.org/10.1007/s10165-006-0490-6

Other articles of this Issue 4/2006

Modern Rheumatology 4/2006 Go to the issue

ORIGINAL ARTICLE

CD19/22 balance relates to improvement of disease activity in systemic lupus erythematosus

CASE REPORT

Infectious myositis involving the piriformis in a patient with rheumatoid arthritis

ORIGINAL ARTICLE

Significant elevation of IgG anti-WRN (RecQ3 RNA/DNA helicase) antibody in systemic sclerosis

CASE REPORT

Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa

ORIGINAL ARTICLE

The clinical application of etanercept in Chinese patients with rheumatic diseases

CASE REPORT

A case of systemic lupus erythematosus expressing intractable thrombocytopenia remedied effectively by intermittent and continuous administrations of a small amount of immune globulin
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits