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Open Access 01-02-2021 | Intracranial Aneurysm | Review

Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms

Authors: Joona Hallikainen, Sara Keränen, Jarno Savolainen, Matti Närhi, Anna Liisa Suominen, Pekka Ylöstalo, Jari Kellokoski, Mikko Pyysalo, Pirkko Pussinen, Tuomas Rauramaa, Juhana Frösen

Published in: Neurosurgical Review | Issue 1/2021

Abstract

Degeneration of intracranial aneurysm wall is under active research and recent studies indicate an increased risk of rupture of intracranial aneurysm among patients with periodontal diseases. In addition, oral bacterial DNA has been identified from wall samples of ruptured and unruptured aneurysms. These novel findings led us to evaluate if oral diseases could predispose to pathological changes seen on intracranial aneurysm walls eventually leading to subarachnoid hemorrhage. The aim of this review is to consider mechanisms on the relationship between periodontitis and aneurysm rupture, focusing on recent evidence.

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Title: Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms
Authors: Joona Hallikainen
Sara Keränen
Jarno Savolainen
Matti Närhi
Anna Liisa Suominen
Pekka Ylöstalo
Jari Kellokoski
Mikko Pyysalo
Pirkko Pussinen
Tuomas Rauramaa
Juhana Frösen
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Intracranial Aneurysm
Aneurysm
Aneurysm
Abdominal Aortic Aneurysm
Abdominal Aortic Aneurysm
Periodontal Pathogens
Published in: Neurosurgical Review / Issue 1/2021
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-020-01253-y

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Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms

Abstract

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