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01-07-2016 | Original Article

Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302)

Authors: Eiji Oki, Shoji Tokunaga, Yasunori Emi, Tetsuya Kusumoto, Manabu Yamamoto, Kengo Fukuzawa, Ikuo Takahashi, Sumiya Ishigami, Akihito Tsuji, Hidefumi Higashi, Toshihiko Nakamura, Hiroshi Saeki, Ken Shirabe, Yoshihiro Kakeji, Kenji Sakai, Hideo Baba, Tadashi Nishimaki, Shoji Natsugoe, Yoshihiko Maehara, Kyushu Study Group of Clinical Cancer

Published in: Gastric Cancer | Issue 3/2016

Abstract

Background

The necessity of surgical treatment of liver metastases of gastric cancer is still controversial.

Patients and methods

We conducted a multicenter retrospective cohort study of liver-limited metastasis of gastric cancer treated surgically between 2000 and 2010. In this study, 103 patients were registered, with nine patients excluded from the analysis as they did not meet the eligibility criteria.

Results

Of the 94 patients, 69 underwent surgical resection, 11 underwent surgical resection combined with radiofrequency ablation or microwave coagulation therapy for small or deep tumors, and 14 underwent radiofrequency ablation or microwave coagulation therapy only. Synchronous and metachronous metastases were found in 37 and 57 patients, respectively. The 3- and 5-year overall survival rates of all the patients were 51.4 and 42.3 %, respectively. The 3- and 5-year relapse-free survival rates were 29.2 and 27.7 %, respectively. No significant difference in prognosis was observed between the patients who underwent surgical resection and those who underwent ablation therapy. The patients with hepatic solitary lesions and low-grade lymph node metastases of primary gastric cancer had significantly better overall survival and relapse-free survival.

Conclusions

To our knowledge, this study is the largest series and first multicenter cohort study of liver-limited metastasis of gastric cancer. The study indicated that patients with a single liver metastasis with a grade lower than N2 lymph node metastasis of the primary lesion are the best candidates for liver resection.

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Title: Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302)
Authors: Eiji Oki
Shoji Tokunaga
Yasunori Emi
Tetsuya Kusumoto
Manabu Yamamoto
Kengo Fukuzawa
Ikuo Takahashi
Sumiya Ishigami
Akihito Tsuji
Hidefumi Higashi
Toshihiko Nakamura
Hiroshi Saeki
Ken Shirabe
Yoshihiro Kakeji
Kenji Sakai
Hideo Baba
Tadashi Nishimaki
Shoji Natsugoe
Yoshihiko Maehara
Kyushu Study Group of Clinical Cancer
Publication date: 01-07-2016
Publisher: Springer Japan
Published in: Gastric Cancer / Issue 3/2016
Print ISSN: 1436-3291
Electronic ISSN: 1436-3305
DOI: https://doi.org/10.1007/s10120-015-0530-z

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Abstract

Background

Patients and methods

Results

Conclusions

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