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01-05-2010 | Original Article

Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study

Authors: Renata Rodrigues de Carvalho, Fernanda de Paula Eduardo, Karen Müller Ramalho, José Leopoldo Ferreira Antunes, Letícia Mello Bezinelli, Marina Helena Cury Gallottini de Magalhães, Tatiana Pegoretti, Patrícia Moreira de Freitas, Carlos de Paula Eduardo

Published in: Lasers in Medical Science | Issue 3/2010

Abstract

Alternative treatment for recurrent labial infection by herpes simplex virus (HSV) have been considered. The aim of this study was to evaluate the effectiveness of laser phototherapy in prevention and reduction of severity of labial manifestations of herpes labialis virus. Seventy-one patients, divided into experimental (n = 41) and control (n = 30) groups were followed up for 16 months. Patients in the control group were treated topically with aciclovir and patients in the experimental group were subjected to laser phototherapy (one session per week, 10 weeks): 780 nm, 60 mW, 3.0 J/cm² or 4.5 J/cm² on healthy (no HSV-1 infection) and affected (with HSV-1 infection) tissues. Patients in the experimental group presented a significant decrease in dimension of herpes labialis lesions (P = 0.013) and inflammatory edema (P = 0.031). The reduction in pain level (P = 0.051) and monthly recurrences (P = 0.076) did not reach statistical significance. This study represents an in vivo indication that this treatment should be further considered as an effective alternative to therapeutic regimens for herpes labialis lesions.

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Title: Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study
Authors: Renata Rodrigues de Carvalho
Fernanda de Paula Eduardo
Karen Müller Ramalho
José Leopoldo Ferreira Antunes
Letícia Mello Bezinelli
Marina Helena Cury Gallottini de Magalhães
Tatiana Pegoretti
Patrícia Moreira de Freitas
Carlos de Paula Eduardo
Publication date: 01-05-2010
Publisher: Springer-Verlag
Published in: Lasers in Medical Science / Issue 3/2010
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-009-0717-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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