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Published in: European Journal of Clinical Microbiology & Infectious Diseases 9/2005

01-09-2005 | Concise article

Pulmonary mycetoma caused by an atypical isolate of Paecilomyces species in an immunocompetent individual: case report and literature review of Paecilomyces lung infections

Authors: F. Gutiérrez, M. Masiá, J. Ramos, M. Elía, E. Mellado, M. Cuenca-Estrella

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 9/2005

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Abstract

The first case of pulmonary fungus ball caused by Paecilomyces species is reported. The diagnosis was established by isolation of the fungus in culture from specimens obtained by percutaneous transthoracic needle aspiration in an immunocompetent individual. The isolate was atypical, as it failed to produce fruiting structures on routine mycological media. Identification was achieved by sequencing polymorphisms of the internal transcriber spacer regions of the ribosomal DNA. The antifungal susceptibility profile was also determined. This report underscores the increasing importance of Paecilomyces species in human infections. Paecilomyces should be included among the etiological agents of pulmonary mycetoma.
Literature
1.
go back to reference Sigler L, Kennedy MJ (1999) Aspergillus, Fusarium, and other opportunistic moniliaecious fungi. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (eds) Manual of clinical microbiology, 7th edn. Washington DC, pp 1231–1235 Sigler L, Kennedy MJ (1999) Aspergillus, Fusarium, and other opportunistic moniliaecious fungi. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (eds) Manual of clinical microbiology, 7th edn. Washington DC, pp 1231–1235
2.
go back to reference Castro LGM, Salebian A, Sotto MN (1990) Hyalohyphomycosis by Paecilomyces lilacinus in a renal transplant patient and a review of human Paecilomyces species infections. J Med Vet Mycol 28:15–26PubMedCrossRef Castro LGM, Salebian A, Sotto MN (1990) Hyalohyphomycosis by Paecilomyces lilacinus in a renal transplant patient and a review of human Paecilomyces species infections. J Med Vet Mycol 28:15–26PubMedCrossRef
3.
go back to reference Williamson PR, Kwong-Chung KL, Gallin JI (1992) Successful treatment of Paecilomyces variotii infection in a patient with chronic granulomatous disease and a review of Paecilomyces species infections. Clin Infect Dis 14:1023–1026PubMed Williamson PR, Kwong-Chung KL, Gallin JI (1992) Successful treatment of Paecilomyces variotii infection in a patient with chronic granulomatous disease and a review of Paecilomyces species infections. Clin Infect Dis 14:1023–1026PubMed
4.
go back to reference Gutiérrez Rodero F, Moragon M, Ortiz de la Tabla V, Mayol MJ, Martin C (1999) Cutaneous hyalohyphomycosis caused by Paecilomyces lilacinus in an immunocompetent host successfully treated with itraconazole: case report and review. Eur J Clin Microbiol Infect Dis 18:814–818CrossRefPubMed Gutiérrez Rodero F, Moragon M, Ortiz de la Tabla V, Mayol MJ, Martin C (1999) Cutaneous hyalohyphomycosis caused by Paecilomyces lilacinus in an immunocompetent host successfully treated with itraconazole: case report and review. Eur J Clin Microbiol Infect Dis 18:814–818CrossRefPubMed
5.
go back to reference Carey J, D'Amico R, Sutton DA, Rinaldi MG (2003) Paecilomyces lilacinus vaginitis in an immunocompetent patient. Emerg Infect Dis 9:1155–1158PubMed Carey J, D'Amico R, Sutton DA, Rinaldi MG (2003) Paecilomyces lilacinus vaginitis in an immunocompetent patient. Emerg Infect Dis 9:1155–1158PubMed
6.
go back to reference Gucalp R, Carlisle P, Gialanella P, Mitsudo S, McKitrick J, Dutcher J (1996) Paecilomyces sinusitis in an immunocompetent adult patient: case report and review. Clin Infect Dis 23:391–393PubMed Gucalp R, Carlisle P, Gialanella P, Mitsudo S, McKitrick J, Dutcher J (1996) Paecilomyces sinusitis in an immunocompetent adult patient: case report and review. Clin Infect Dis 23:391–393PubMed
7.
go back to reference Scott IU, Flynn HW Jr, Miller D, Speights JW, Snip RC, Brod RD (2001) Exogenous endophthalmitis caused by amphotericin B-resistant Paecilomyces lilacinus: treatment options and visual outcomes. Arch Ophthalmol 119:916–919PubMed Scott IU, Flynn HW Jr, Miller D, Speights JW, Snip RC, Brod RD (2001) Exogenous endophthalmitis caused by amphotericin B-resistant Paecilomyces lilacinus: treatment options and visual outcomes. Arch Ophthalmol 119:916–919PubMed
8.
go back to reference Wilhelmus KR, Robinson NM, Font RA, Hamill MB, Jones DB (1998) Fungal keratitis in contact lens wearers. Am J Ophthalmol 106:708–714 Wilhelmus KR, Robinson NM, Font RA, Hamill MB, Jones DB (1998) Fungal keratitis in contact lens wearers. Am J Ophthalmol 106:708–714
9.
go back to reference Martin CA, Roberts S, Greenberg RN (2002) Voriconazole treatment of disseminated Paecilomyces infection in a patient with acquired immunodeficiency syndrome. Clin Infect Dis 35:e78–e81CrossRefPubMed Martin CA, Roberts S, Greenberg RN (2002) Voriconazole treatment of disseminated Paecilomyces infection in a patient with acquired immunodeficiency syndrome. Clin Infect Dis 35:e78–e81CrossRefPubMed
10.
go back to reference Chan-Tack KM, Thio CL, Miller NS, Karp CL, Ho C, Merz WG (1999) Paecilomyces lilacinus fungemia in an adult bone marrow transplant recipient. Med Mycol 37:57–60CrossRefPubMed Chan-Tack KM, Thio CL, Miller NS, Karp CL, Ho C, Merz WG (1999) Paecilomyces lilacinus fungemia in an adult bone marrow transplant recipient. Med Mycol 37:57–60CrossRefPubMed
11.
go back to reference Dharmasena FM, Davies GS, Catovsky D (1985) Paecilomyces variotii pneumonia complicating hairy cell leukaemia. Br Med J 290:967–968CrossRef Dharmasena FM, Davies GS, Catovsky D (1985) Paecilomyces variotii pneumonia complicating hairy cell leukaemia. Br Med J 290:967–968CrossRef
12.
go back to reference Chan TH, Koehler A, Li PK (1996) Paecilomyces variotii peritonitis in patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis 27:138–142PubMed Chan TH, Koehler A, Li PK (1996) Paecilomyces variotii peritonitis in patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis 27:138–142PubMed
13.
go back to reference Cohen-Abbo A, Edwards KM (1995) Multifocal osteomyelitis caused by Paecilomyces variotii in a patient with chronic granulomatous disease. Infection 23:55–57CrossRefPubMed Cohen-Abbo A, Edwards KM (1995) Multifocal osteomyelitis caused by Paecilomyces variotii in a patient with chronic granulomatous disease. Infection 23:55–57CrossRefPubMed
14.
go back to reference Kalish SB, Goldschmidt R, Li C, Knop R, Cook FV, Wilner G, Victor TA (1982) Infective endocarditis caused by Paecilomyces variotii. Am J Clin Pathol 78:249–252PubMed Kalish SB, Goldschmidt R, Li C, Knop R, Cook FV, Wilner G, Victor TA (1982) Infective endocarditis caused by Paecilomyces variotii. Am J Clin Pathol 78:249–252PubMed
15.
go back to reference Fenech FF, Mallia CP (1972) Pleural effusion caused by Penicillium lilacinum. Br J Dis Chest 66:284–290CrossRefPubMed Fenech FF, Mallia CP (1972) Pleural effusion caused by Penicillium lilacinum. Br J Dis Chest 66:284–290CrossRefPubMed
16.
go back to reference Mellado E, Diaz-Guerra TM, Cuenca-Estrella M, Rodriguez-Tudela JL (2001) Identification of two different 14-a sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species. J Clin Microbiol 39:2431–2438CrossRefPubMed Mellado E, Diaz-Guerra TM, Cuenca-Estrella M, Rodriguez-Tudela JL (2001) Identification of two different 14-a sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species. J Clin Microbiol 39:2431–2438CrossRefPubMed
17.
go back to reference National Committee for Clinical Laboratory Standards (2002) Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard M38-A. NCCLS, Wayne, PA National Committee for Clinical Laboratory Standards (2002) Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard M38-A. NCCLS, Wayne, PA
18.
go back to reference Rodriguez-Tudela JL, Chryssanthou E, Petrikkou E, Mosquera J, Dennning DW, Cuenca-Estrella M (2003) Interlaboratory evaluation of hematocytometer method of inoculum preparation for testing antifungal susceptibilities of filamentous fungi. J Clin Microbiol 41:5236–5237CrossRefPubMed Rodriguez-Tudela JL, Chryssanthou E, Petrikkou E, Mosquera J, Dennning DW, Cuenca-Estrella M (2003) Interlaboratory evaluation of hematocytometer method of inoculum preparation for testing antifungal susceptibilities of filamentous fungi. J Clin Microbiol 41:5236–5237CrossRefPubMed
19.
go back to reference Denning DW, Radford SA, Oakley KL, Hall L, Johnson EM, Warnock DW (1997) Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection. J Antimicrob Chemother 40:401–414CrossRefPubMed Denning DW, Radford SA, Oakley KL, Hall L, Johnson EM, Warnock DW (1997) Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection. J Antimicrob Chemother 40:401–414CrossRefPubMed
20.
go back to reference Byrd RP Jr, Roy TM, Fields CL, Lynch JA (1992) Paecilomyces variotii pneumonia in a patient with diabetes mellitus. J Diabetes its Complicat 6:150–153CrossRef Byrd RP Jr, Roy TM, Fields CL, Lynch JA (1992) Paecilomyces variotii pneumonia in a patient with diabetes mellitus. J Diabetes its Complicat 6:150–153CrossRef
21.
go back to reference Sillevis JH, Leusen JH, Stas HG, Teeuw AH, Weeningb RS (1997) Chronic bullous disease of childhood and a Paecilomyces lung infection in chronic granulomatous disease. Arch Dis Child 77:150–152PubMed Sillevis JH, Leusen JH, Stas HG, Teeuw AH, Weeningb RS (1997) Chronic bullous disease of childhood and a Paecilomyces lung infection in chronic granulomatous disease. Arch Dis Child 77:150–152PubMed
22.
go back to reference Ono N, Sato K, Yokomise H, Tamura K (1999) Lung abscess caused by Paecilomyces lilacinus. Respiration 66:85–87CrossRefPubMed Ono N, Sato K, Yokomise H, Tamura K (1999) Lung abscess caused by Paecilomyces lilacinus. Respiration 66:85–87CrossRefPubMed
23.
go back to reference Das A, MacLaughlin EF, Ross LA, Monforte HL, Horn MV, Lam GL, Mason WH (2000) Paecilomyces variotii in a pediatric patient with lung transplantation. Pediatr Transplant 4:328–432CrossRefPubMed Das A, MacLaughlin EF, Ross LA, Monforte HL, Horn MV, Lam GL, Mason WH (2000) Paecilomyces variotii in a pediatric patient with lung transplantation. Pediatr Transplant 4:328–432CrossRefPubMed
24.
go back to reference Ortoneda M, Capilla J, Pastor FJ, Pujol I, Yustes C, Serena C, Guarro J (2004) In vitro interactions of approved and novel drugs against Paecilomyces spp. Antimicrob Agents Chemother 48:2727–2729CrossRefPubMed Ortoneda M, Capilla J, Pastor FJ, Pujol I, Yustes C, Serena C, Guarro J (2004) In vitro interactions of approved and novel drugs against Paecilomyces spp. Antimicrob Agents Chemother 48:2727–2729CrossRefPubMed
25.
go back to reference Perfect JR, Schell WA (1996) The new fungal opportunists are coming. Clin Infect Dis 22(Suppl 2):112–118 Perfect JR, Schell WA (1996) The new fungal opportunists are coming. Clin Infect Dis 22(Suppl 2):112–118
26.
go back to reference Espinel-Ingroff A (2001) In vitro fungicidal activities of voriconazole, itraconazole, and amphotericin B against opportunistic moniliaceous and dematiaceous fungi. J Clin Microbiol 39:954–958CrossRefPubMed Espinel-Ingroff A (2001) In vitro fungicidal activities of voriconazole, itraconazole, and amphotericin B against opportunistic moniliaceous and dematiaceous fungi. J Clin Microbiol 39:954–958CrossRefPubMed
27.
go back to reference Hilmarsdottir I, Thorsteinsson SB, Asmundsson P, Bodvarsson M, Arnadottir M (2000) Cutaneous infection caused by Paecilomyces lilacinus in a renal transplant patient: treatment with voriconazole. Scand J Infect Dis 32:331–332CrossRefPubMed Hilmarsdottir I, Thorsteinsson SB, Asmundsson P, Bodvarsson M, Arnadottir M (2000) Cutaneous infection caused by Paecilomyces lilacinus in a renal transplant patient: treatment with voriconazole. Scand J Infect Dis 32:331–332CrossRefPubMed
28.
go back to reference Garbino J, Ondrusova A, Baglivo E, Lew D, Bouchuiguir-Wafa K, Rohner P (2002) Successful treatment of Paecilomyces lilacinus endophthalmitis with voriconazole. Scand J Infect Dis 34:701–703CrossRefPubMed Garbino J, Ondrusova A, Baglivo E, Lew D, Bouchuiguir-Wafa K, Rohner P (2002) Successful treatment of Paecilomyces lilacinus endophthalmitis with voriconazole. Scand J Infect Dis 34:701–703CrossRefPubMed
29.
go back to reference Soubani AO, Chandrasekar PH (2002) The clinical spectrum of pulmonary aspergillosis. Chest 121:1988–1999CrossRefPubMed Soubani AO, Chandrasekar PH (2002) The clinical spectrum of pulmonary aspergillosis. Chest 121:1988–1999CrossRefPubMed
Metadata
Title
Pulmonary mycetoma caused by an atypical isolate of Paecilomyces species in an immunocompetent individual: case report and literature review of Paecilomyces lung infections
Authors
F. Gutiérrez
M. Masiá
J. Ramos
M. Elía
E. Mellado
M. Cuenca-Estrella
Publication date
01-09-2005
Publisher
Springer-Verlag
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 9/2005
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-005-0013-y

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