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European Journal of Clinical Microbiology & Infectious Diseases
Published in: European Journal of Clinical Microbiology & Infectious Diseases 9/2003

01-09-2003 | Concise Article

Plasmodium falciparum Cerebral Malaria Complicated by Disseminated Intravascular Coagulation and Symmetrical Peripheral Gangrene: Case Report and Review

Authors: M. E. Liechti, V. Zumsteg, C. F. R. Hatz, T. Herren

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 9/2003

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Abstract

The case of a 56-year-old female tourist who survived cerebral Plasmodium falciparum malaria with disseminated intravascular coagulation and symmetrical peripheral gangrene, ultimately requiring amputation of her left-sided fingertips and toes, is reported. While symmetrical peripheral gangrene has been described rarely in Asian, African, and American patients with Plasmodium falciparum malaria and disseminated intravascular coagulation, no such case has been reported in travelers returning from endemic areas.
Literature
1.
Jelinek T, Schulte C, Behrens R, Grobusch MP, Coulaud JP, Bisoffi Z, Matteelli A, Clerinx J, Corachan M, Puente S et al. (2002) Imported falciparum malaria in Europe: sentinel surveillance data from the European Network on Surveillance of Imported Infectious Diseases. Clin Infect Dis 34:572–576CrossRefPubMed
2.
MacPherson GG, Warrell MJ, White NJ, Looareesuwan S, Warrell DA (1985) Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am J Pathol 119:385–401
3.
Jaroonvesama N (1972) Intravascular coagulation in falciparum malaria. Lancet i:221–223
4.
World Health Organization, Communicable Diseases Cluster (2000) Severe falciparum malaria. Trans R Soc Trop Med Hyg 94 (Suppl 1):1–90PubMed
5.
Bruneel F, Hocqueloux L, Alberti C, Wolff M, Chevret S, Bedos JP, Durand R, Le Bras J, Regnier B, Vachon F (2003) The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults. Am J Respir Crit Care Med 167:684–689CrossRefPubMed
6.
Clemens R, Pramoolsinsap C, Lorenz R, Pukrittayakamee S, Bock HL, White NJ (1994) Activation of the coagulation cascade in severe falciparum malaria through the intrinsic pathway. Br J Haematol 87:100–105PubMed
7.
Losert H, Schmid K, Wilfing A, Winkler S, Staudinger T, Kletzmayr J, Burgmann H (2000) Experiences with severe P. falciparum malaria in the intensive care unit. Intensive Care Med 26:195–201CrossRefPubMed
8.
Anuradha S, Prabhash K, Shome DK, Gaiha M, Singh NP, Agarwal SK, Mandal AK, Jain S, Chaturvedi KU, Sawlani KK (1999) Symmetric peripheral gangrene and falciparum malaria—an interesting association. J Assoc Physicians India 47:733–735PubMed
9.
Edwards IR (1980) Malaria with disseminated intravascular coagulation and peripheral tissue necrosis successfully treated with streptokinase. Br Med J 280:1252–1253PubMed
10.
Kochar Shubhakaran DK, Kumawat B, Kochar SK (1998) A patient with falciparum malaria and bilateral gangrene of the feet who developed arrhythmia/ventricular fibrillation after quinine therapy. QJM 91:246CrossRefPubMed
11.
Chittichai P, Chierakul N, Davis TM (1991) Peripheral gangrene in nonfatal pediatric cerebral malaria: a report of two cases. Southeast Asian J Trop Med Public Health 22:190–194PubMed
12.
Jain D, Srivastave S, Singhal SS (1995) A rare presentation of falciparum malaria. J Assoc Physicians India 43:582PubMed
13.
Sharma SN (1987) Cutaneous gangrene in falciparum malaria: an unreported manifestation. J Assoc Physicians India 35:150–152PubMed
14.
Keri JE, Thomas K, Berman B, Falabella A (2000) Purpura fulminans in a patient with malaria. Eur J Dermatol 10:617–619PubMed
15.
Mohanty D, Ghosh K, Nandwani SK, Shetty S, Phillips C, Rizvi S, Parmar BD (1997) Fibrinolysis, inhibitors of blood coagulation, and monocyte-derived coagulant activity in acute malaria. Am J Hematol 54:23–29CrossRefPubMed
16.
Maguire PA, Prudhomme J, Sherman IW (1991) Alterations in erythrocyte membrane phospholipid organization due to the intracellular growth of the human malaria parasite, Plasmodium falciparum. Parasitology 102:179–186PubMed
17.
Mohanty D, Marwaha N, Ghosh K, Chauhan AP, Shah S, Sharma S, Das KC (1985) Vascular occlusion and disseminated intravascular coagulation in falciparum malaria. Br Med J 290:115–116
18.
Schwartz RS, Olson JA, Raventos-Suarez C, Yee M, Heath RH, Lubin B, Nagel RL (1987) Altered plasma membrane phospholipid organization in Plasmodium falciparum-infected human erythrocytes. Blood 69:401–407PubMed
19.
Zwaal RF, Schroit AJ (1997) Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 89:1121–1132
20.
Hemmer CJ, Kern P, Holst FG, Radtke KP, Egbring R, Bierhaus A, Nawroth PP, Dietrich M (1991) Activation of the host response in human Plasmodium falciparum malaria: relation of parasitemia to tumor necrosis factor/cachectin, thrombin-antithrombin III, and protein C levels. Am J Med 91:37–44PubMed
21.
Levi M, Ten Cate H (1999) Disseminated intravascular coagulation. N Engl J Med 341:586–592PubMed
22.
Davis MP, Byrd J, Lior T, Rooke TW (2001) Symmetrical peripheral gangrene due to disseminated intravascular coagulation. Arch Dermatol 137:139–140PubMed
23.
Hemmer CJ, Kern P, Holst FG, Nawroth PP, Dietrich M (1991) Neither heparin nor acetylsalicylic acid influence the clinical course in human Plasmodium falciparum malaria: a prospective randomized study. Am J Trop Med Hyg 45:608–612PubMed
24.
Riddle MS, Jackson JL, Sanders JW, Blazes DL (2002) Exchange transfusion as an adjunct therapy in severe Plasmodium falciparum malaria: a meta-analysis. Clin Infect Dis 34:1192–1198CrossRefPubMed
Metadata
Title
Plasmodium falciparum Cerebral Malaria Complicated by Disseminated Intravascular Coagulation and Symmetrical Peripheral Gangrene: Case Report and Review
Authors
M. E. Liechti
V. Zumsteg
C. F. R. Hatz
T. Herren
Publication date
01-09-2003
Publisher
Springer-Verlag
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 9/2003
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-003-0984-5

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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