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01-04-2015 | Original Article

Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine

Authors: Fengzhi Wang, Qiu He, Zhanxiu Ren, Fuyong Li, Wei Chen, Xiang Lin, Hemin Zhang, Guofeng Tai

Published in: Neurological Sciences | Issue 4/2015

Abstract

To investigate the associations of serum levels of intercellular adhesion molecule-1 (ICAM1) and the pro-inflammatory cytokine interleukin-6 (IL-6) with migraine and migraine subtypes, and to study their correlation with each other in this condition. We used enzyme-linked immunosorbent assay to measure serum levels of ICAM1 and IL-6 in 103 migraine patients with and without aura, in both attack and pain-free periods, and in 100 healthy control subjects. Serum levels of ICAM1 and IL-6 were significantly higher in migraine patients during attacks than in controls (p < 0.05). Serum ICAM1 levels were significantly higher in migraine with aura (MA) than in migraine without aura (MO), (p < 0.05). Correlation analysis indicated a significant positive correlation between serum levels of ICAM1 and IL-6 (p < 0.05) in migraine patients during attacks. Our results indicate that ICAM1 and IL-6 are involved in the pathogenesis of migraine attacks, possibly via an interactive mechanism.

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Title: Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine
Authors: Fengzhi Wang
Qiu He
Zhanxiu Ren
Fuyong Li
Wei Chen
Xiang Lin
Hemin Zhang
Guofeng Tai
Publication date: 01-04-2015
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 4/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-2010-3

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Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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