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01-01-2015 | Original Article

Val158Met polymorphism of COMT gene and Parkinson’s disease risk in Asians

Authors: Lixue Chuan, Jie Gao, Yuying Lei, Raoxiang Wang, Lechun Lu, Xianyu Zhang

Published in: Neurological Sciences | Issue 1/2015

Abstract

In previous study, we have found the catechol-O-methyltransferase (COMT) Val158Met polymorphism as an associated risk factor for Parkinson’s disease (PD) in Asian rather than Caucasian populations. The aim of this study was to further evaluate the associations of PD risk with COMT polymorphisms in different Asian populations. We carried out a retrieval of studies that investigated associations between COMT Val158Met polymorphism and PD risk in Asians, and included the study if it met the eligibility criteria. Stata version 12.0 was used to analyze the data. A total of 13 studies including 1,834 patients and 2,298 controls were included. The overall result indicated that COMT Val158Met polymorphism was significantly associated with the risk of PD in Asians (AA vs others: OR = 1.58, 95 % CI 1.26–1.97, p < 0.001; GG vs AA: OR = 0.63, 95 % CI 0.47–0.85, p = 0.002; AA vs GA: OR = 1.58, 95 % CI 1.24–2.00, p < 0.001). In Japanese population, the homozygote AA tends to increase the risk of PD (AA vs others: OR = 1.54, 95 % CI 1.10–2.15, p = 0.012; AA vs GA: OR = 1.61, 95 % CI 1.14–2.29, p = 0.008). This study showed that the Val158Met polymorphism of COMT gene may be associated with PD in Japanese rather than Chinese population. Further studies are needed to confirm this association in more ethnicities.

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Title: Val158Met polymorphism of COMT gene and Parkinson’s disease risk in Asians
Authors: Lixue Chuan
Jie Gao
Yuying Lei
Raoxiang Wang
Lechun Lu
Xianyu Zhang
Publication date: 01-01-2015
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 1/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1896-0

Keynote webinar | Spotlight on medication adherence

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Val158Met polymorphism of COMT gene and Parkinson’s disease risk in Asians

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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