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01-10-2014 | Original Article

Trans-anethole protects cortical neuronal cells against oxygen–glucose deprivation/reoxygenation

Authors: Sangwoo Ryu, Geun Hee Seol, Hyeon Park, In-Young Choi

Published in: Neurological Sciences | Issue 10/2014

Abstract

Trans-anethole has been studied on pharmacological properties such as anti-inflammation, anti-oxidative stress, antifungal and anticancer. However, to date, the anti-ischemic effects of trans-anethole have not been assessed. Therefore, we investigated the neuroprotection of trans-anethole against oxygen–glucose deprivation/reoxygenation (OGD/R)-induced cortical neuronal cell injury, an in vitro model of ischemia. The abilities of trans-anethole to block excitotoxicity, oxidative stress and mitochondrial dysfunction were evaluated in OGD/R-induced neurons. Trans-anethole significantly ameliorated OGD/R-induced neuronal cell injury by attenuating the intracellular calcium overload via the activation of NMDA receptors. Trans-anethole also inhibited OGD/R-induced reactive oxygen species overproduction, which may be derived from the scavenging activity in peroxyl radicals, assessed in an oxygen radical absorbance capacity assay. Furthermore, trans-anethole was shown to attenuate the depolarization of mitochondrial transmembrane. These results indicated that the neuroprotective effect of trans-anethole on OGD/R-induced neuronal injury might be due to its ability to inhibit excitotoxicity, oxidative stress and mitochondrial dysfunction. Considering these multiple pathways causing ischemic neuronal damage, the multi-functional effect of trans-anethole suggested that it may be effective in treating ischemic stroke.

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Title: Trans-anethole protects cortical neuronal cells against oxygen–glucose deprivation/reoxygenation
Authors: Sangwoo Ryu
Geun Hee Seol
Hyeon Park
In-Young Choi
Publication date: 01-10-2014
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 10/2014
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1791-8

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Trans-anethole protects cortical neuronal cells against oxygen–glucose deprivation/reoxygenation

Abstract

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Abstract

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