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Clinical Rheumatology
Published in: Clinical Rheumatology 12/2020

01-12-2020 | Pneumonia | Original Article

IPAF should receive early treatment for sharing similar clinical characteristics as CTD-ILD: a report from 273 Chinese patients

Authors: Ying Li, ZhaoHui Zheng, Qing Han, ZhiQin Li, RongHua Xie, Rui Zhang, Bei Zhang, Ping Zhu

Published in: Clinical Rheumatology | Issue 12/2020

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Abstract

Objectives

The clinical characteristics of interstitial pneumonia with autoimmune features (IPAF) and connective tissue disease interstitial lung disease (CTD-ILD) have not been adequately compared. We compared the clinical characteristics of these two conditions and analyzed the changes in lung function before and after treatment of IPAF.

Methods

A total of 412 patients were enrolled in the study, and their clinical characteristics were assessed. The treatment-related changes in 12 cases of IPAF were analyzed.

Results

Complete clinical data were available for 126 patients with CTD-ILD and 147 with IPAF. All IPAF patients showed autoantibody positivity. The proportion of patients showing extrapulmonary symptoms in the CTD-ILD group was higher than that in the IPAF group (P < 0.05). Patients with IPAF demonstrated lower P(A-a)O2 and higher PaO2 and PaCO2 than those with CTD-ILD (P < 0.05 for all comparisons). Forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO) in IPAF patients were higher than those in CTD-ILD patients (P = 0.023 for FVC; P = 0.011 for DLCO). Among patients with IPAF, only the proportions of honeycombing and nodules were lower than those in CTD-ILD patients (P < 0.05). Both FVC and DLCO values increased after treatment in patients with IPAF (P < 0.05).

Conclusion

IPAF showed autoantibody positivity and similar computed tomography (CT) findings as CTD-ILD, and lung function in patients with IPAF improved after immunosuppressive treatment, indicating that IPAF should receive attention and early immunosuppressive treatment like CTD-ILD, even though IPAF exhibits no extrapulmonary symptoms.
Key Points
• Clinical characteristics of IPAF
Appendix
Available only for authorised users
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Metadata
Title
IPAF should receive early treatment for sharing similar clinical characteristics as CTD-ILD: a report from 273 Chinese patients
Authors
Ying Li
ZhaoHui Zheng
Qing Han
ZhiQin Li
RongHua Xie
Rui Zhang
Bei Zhang
Ping Zhu
Publication date
01-12-2020
Publisher
Springer International Publishing
Keyword
Pneumonia
Published in
Clinical Rheumatology / Issue 12/2020
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-020-05149-6

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