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Journal of Artificial Organs
Published in: Journal of Artificial Organs 3/2012

01-09-2012 | Review

Bioactive polymer scaffold for fabrication of vascularized engineering tissue

Author: Irza Sukmana

Published in: Journal of Artificial Organs | Issue 3/2012

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Abstract

Tissue engineering seeks strategies to design polymeric scaffolds that allow high-cell-density cultures with signaling molecules and suitable vascular supply. One major obstacle in tissue engineering is the inability to create thick engineered-tissue constructs. A pre-vascularized tissue scaffold appears to be the most favorable approach to avoid nutrient and oxygen supply limitations as well as to allow waste removal, factors that are often hurdles in developing thick engineered tissues. Vascularization can be achieved using strategies in which cells are cultured in bioactive polymer scaffolds that can mimic extracellular matrix environments. This review addresses recent advances and future challenges in developing and using bioactive polymer scaffolds to promote tissue construct vascularization.
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Metadata
Title
Bioactive polymer scaffold for fabrication of vascularized engineering tissue
Author
Irza Sukmana
Publication date
01-09-2012
Publisher
Springer Japan
Published in
Journal of Artificial Organs / Issue 3/2012
Print ISSN: 1434-7229
Electronic ISSN: 1619-0904
DOI
https://doi.org/10.1007/s10047-012-0644-6

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