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Published in: Brain Tumor Pathology 2/2019

01-04-2019 | Astrocytoma | Review Article

Molecular genetics and therapeutic targets of pediatric low-grade gliomas

Authors: Kensuke Tateishi, Taishi Nakamura, Tetsuya Yamamoto

Published in: Brain Tumor Pathology | Issue 2/2019

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Abstract

Pediatric low-grade gliomas (PLGGs) have relatively favorable prognosis and some resectable PLGGs, such as cerebellar pilocytic astrocytoma, can be cured by surgery alone. However, many PLGG cases are unresectable and some of them undergo tumor progression. Therefore, a multidisciplinary approach is necessary to treat PLGG patients. Recent genomic analysis revealed a broad genomic landscape underlying PLGG. Notably, the majority of PLGGs present MAPK pathway-associated genomic alterations and MAPK signaling-dependent tumor progression. Following preclinical evidence, many clinical trials based on molecular target therapy have been conducted on PLGG patients, some of whom exhibited durable response to target therapy. Here, we provide an overview of PLGG genetics and the evidence supporting the application of molecular target therapy in these patients.
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Metadata
Title
Molecular genetics and therapeutic targets of pediatric low-grade gliomas
Authors
Kensuke Tateishi
Taishi Nakamura
Tetsuya Yamamoto
Publication date
01-04-2019
Publisher
Springer Singapore
Published in
Brain Tumor Pathology / Issue 2/2019
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI
https://doi.org/10.1007/s10014-019-00340-3

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Preface

Preface

Acknowledgment

Reviewers in 2018