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01-06-2010 | Original Article

MAGE-A antigens in patients with primary oral squamous cell carcinoma

Authors: Urs D. A. Müller-Richter, Albert Dowejko, Silvia Peters, Stephan Rauthe, Tobias Reuther, Stefan Gattenlöhner, Torsten E. Reichert, Oliver Driemel, Alexander C. Kübler

Published in: Clinical Oral Investigations | Issue 3/2010

Abstract

MAGE-A antigens are only expressed on tumor cells. The aim of this study was to identify their expression in patients with oral squamous cell carcinoma (OSCC). Forty-seven patients with primary OSCC was selected retrospectively. Histo-pathological sections were stained immunohistochemically with MAGE-A antibody 57B. The results were evaluated regarding tumor size (T), lymph-node metastasis (N), blood vessel infiltration (V), lymph vessel infiltration (L), grading (G), and sex. MAGE-A antigens were expressed in 55% of all patients. Expression increased with tumor size (T1 = 56%; T2 = 44%; T3 = 67%; T4 = 71%). Lymph-node metastasis had no influence (N0 and N1 about 50%). Tumors with blood and lymph vessel infiltration had higher expression (V0 = 50%; V1 = 100%; L0 = 46%; L1 = 71%). Less-differentiated tumors showed higher rates (G1 = 50%; G2 = 45%; G3 = 83%). OSCC in men were positive in 62% and in women in 38%. MAGE-A antigens are frequently expressed in OSCC. Their expression seems to increase with tumor dedifferentiation.

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Title: MAGE-A antigens in patients with primary oral squamous cell carcinoma
Authors: Urs D. A. Müller-Richter
Albert Dowejko
Silvia Peters
Stephan Rauthe
Tobias Reuther
Stefan Gattenlöhner
Torsten E. Reichert
Oliver Driemel
Alexander C. Kübler
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 3/2010
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-009-0292-2

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MAGE-A antigens in patients with primary oral squamous cell carcinoma

Abstract

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Abstract

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