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01-12-2007 | Original Article

Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery

Authors: Gonca Cayir Keles, Burcu Ozkan Cetinkaya, Bulent Ayas, Ibrahim Isildak, Emine Diraman, Hulya Koprulu, Gokhan Acikgoz

Published in: Clinical Oral Investigations | Issue 4/2007

Abstract

The hypothesis, a relationship between gingival tissue platelet activating factor (PAF) levels and healing after periodontal surgery, was tested by measuring PAF levels in gingival tissues collected from sites that had undergone flap surgery and guided tissue regeneration (GTR) or flap surgery alone. Using a split-mouth design, 20 intrabony defects were randomly assigned to treatment with flap surgery and GTR (group 1) or with flap surgery alone (group 2). Gingival tissue samples were obtained at surgery (baseline) and at 6-month follow-up evaluation visit. One half of each sample was used for analysis of PAF levels by high-performance liquid chromatography, and the other half of the sample was used for histomorphometric analysis that included measurements of number and diameter of blood vessels. PAF levels and diameter of blood vessels were significantly decreased (p < 0.01), and the number of blood vessels was significantly increased (p < 0.05) in both groups after 6 months compared to the baseline values. Postoperative number of blood vessels were significantly higher in group 1 (p < 0.05), whereas there was no significant difference in postoperative PAF levels between the two groups (p > 0.05). Based on the reported results, it is suggested that a decrease in gingival PAF levels might be found after conventional and regenerative periodontal surgery.

Aimetti M, Romano F, Pigella E, Pranzini F, Debernardi C (2005) Treatment of wide, shallow, and predominantly 1-wall intrabony defects with a bioabsorbable membrane: a randomized controlled clinical trial. J Periodontol 76:1354–1361PubMedCrossRef

Antonopoulou S, Demopoulos CA, Argyropoulos D, Baltas G, Kotsifaki H, Diamanti-Kipioti A (1998) Identification of a new endogenous platelet-activating factor-like molecule in gingival crevicular fluid. Biochem J 330:791–794PubMed

Antonopoulou S, Tsoupras A, Baltas G, Kotsifaki H, Mantzavinos Z, Demopoulos CA (2003) Hydroxyl-platelet-activating factor exists in blood of healthy volunteers and periodontal patients. Mediat Inflamm 12:221–227CrossRef

Bassi F, Marchisella C, Schierano G, Gasser E, Montrucchio G, Valente G, Camussi G, Preti G (2001) Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. J Periodontol 72:57–64PubMedCrossRef

Booth V, Young S, Cruchley A, Taichman NS, Paleolog E (1998) Vascular endothelial growth factor in human periodontal disease. J Periodontal Res 33:491–499PubMedCrossRef

Braquet P, Touqui L, Shen TY, Vargaftig BB (1987) Perspectives in platelet-activating factor research. Pharmacol Rev 39:97–145PubMed

Buduneli E, Vardar S, Buduneli N, Berdeli AH, Turkoglu O, Baskesen A, Atilla G (2004) Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. J Periodontol 75:1516–1523PubMedCrossRef

Camargo PM, Weinlaender M, Madzarevic M (2005) A reentry study on the use of bovine porous bone mineral, GTR, and platelet-rich plasma in the regenerative treatment of intrabony defects in humans. Int J Periodontics Restor Dent 25:49–59

Cetinkaya BO, Acikgoz G, Ayas B, Aliyev E, Sakallioglu EE (2006) Increased expression of vascular endothelial growth factor in cyclosporin A-induced gingival overgrowth in rats. J Periodontol 77:54–60PubMedCrossRef

10.

Cetinkaya BO, Keles GC, Ayas B, Aydin O, Kirtiloglu T, Acikgoz G (2007) Comparison of the proliferative activity in gingival epithelium after surgical treatments of intrabony defects with bioactive glass and bioabsorbable membrane. Clin Oral Investig 11:61–68PubMedCrossRef

11.

Collin-Osdoby P, Rothe L, Bekker S, Anderson F, Huang Y, Osdoby P (2002) Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro. J Bone Miner Res 17:1859–1871PubMedCrossRef

12.

Cortellini P, Carnevale G, Sanz M, Tonetti MS (1998) Treatment of deep and shallow intrabony defects. A multicenter randomized controlled clinical trial. J Clin Periodontol 25:981–987PubMedCrossRef

13.

Cronstein B, Weissman G (1993) The adhesion molecules of inflammation. Arthritis Rheum 36:147–157PubMed

14.

Emingil G, Cinarcik S, Baylas H, Huseyinov A (2001) Levels of platelet-activating factor in gingival crevicular fluid and gingival tissue in specific periodontal diseases. J Periodontol 72:1032–1037PubMedCrossRef

15.

Emingil G, Coker I, Atilla G, Huseyinov A (2000) Levels of leukotriene B4 and platelet activating factor in gingival crevicular fluid in renal transplant patients receiving cyclosporine A. J Periodontol 71:50–57PubMedCrossRef

16.

Flemmig TF (1999) Periodontitis. Ann Periodontol 4:32–38PubMedCrossRef

17.

Garito ML, Prihoda TJ, McManus LM (1995) Salivary PAF levels correlate with the severity of periodontal inflammation. J Dent Res 74:1048–1056PubMedCrossRef

18.

Honig J, Rordorf-Adam C, Siegmund C, Wiedemann W, Erard F (1989) Increased interleukin-1 beta (IL-1 beta) concentration in gingival tissue from periodontitis patients. J Periodontal Res 24:362–367PubMedCrossRef

19.

Hou LT, Liu CM, Liu BY, Lin SJ, Liao CS, Rossomando EF (2003) Interleukin-1beta, clinical parameters and matched cellular–histopathologic changes of biopsied gingival tissue from periodontitis patients. J Periodontal Res 38:247–254PubMedCrossRef

20.

Imai H, Minamibayashi S, Nobuto T, Yanagihara K, Yamaoka A (1995) Changes in the rat periosteal vessels with aging. Part 1. Morphological changes in the microvasculature. Jpn J Concerv Dent 38:106–112

21.

Imai H, Minamibayashi S, Nobuto T, Yanagihara K, Yamaoka A (1995) Changes in the rat periosteal vessels with aging. Part 2. Morphological changes in the vascular permeation mechanism. Jpn J Concerv Dent 38:113–120

22.

Imai H, Minamibayashi S, Nobuto T, Yanagihara K, Yamaoka A (1995) Changes in the rat periosteal vessels with aging. Part 3. Changes vascular permeability. Jpn J Concerv Dent 38:121–129

23.

Jackson J, Seed M, Kircher C, Willoughby D, Winkler J (1997) The codependence of angiogenesis and chronic inflammation. FASEB J 11:457–465PubMed

24.

Johnson RB, Serio FG, Dai X (1999) Vascular endothelial growth factors and progression of periodontal diseases. J Periodontol 70:848–852PubMedCrossRef

25.

Karring T, Nyman S, Gottlow J, Laurell L (1993) Development of the biological concept of guided tissue regeneration-animal and human studies. Periodontol 2000 1:26–35CrossRef

26.

Karring T, Lindhe J, Cortellini P (2003) Regenerative periodontal therapy. In: Lindhe J, Karring T, Lang NP (eds) Clinical periodontology and implant dentistry. Blackwell, Oxford, UK, pp 650–704

27.

Keles GC, Acikgoz G, Ayas B, Sakallioglu E, Firatli E (2005) Determination of systemically and locally induced periodontal defects in rats. Indian J Med Res 121:176–184PubMed

28.

Keles GC, Cetinkaya BO, Isildak I, Koprulu H, Acikgoz G (2006) Levels of platelet activating factor in gingival crevice fluid following periodontal surgical therapy. J Periodontal Res 41:513–518PubMedCrossRef

29.

Koch A (1998) Angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum 41:951–962PubMedCrossRef

30.

Lingen MW (2001) Role of leukocytes and endothelial cells in the development of angiogenesis in inflammation and wound healing. Arch Pathol Lab Med 125:67–71PubMed

31.

Löe H, Silness J (1963) Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 21:533–551PubMedCrossRef

32.

Matsuki Y, Yamamoto T, Hara K (1993) Localization of interleukin-1 (IL-1) mRNA-expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicular fluid. J Periodontal Res 28:35–42PubMedCrossRef

33.

Mayfield L, Soderholm G, Hallstrom H, Kullendorff B, Edwardsson S, Bratthall G, Bragger U, Attstrom R (1998) Guided tissue regeneration for the treatment of intraosseous defects using a biabsorbable membrane. A controlled clinical study. J Clin Periodontol 25:585–595PubMedCrossRef

34.

McGee JM, Tucci MA, Edmundson TP, Serio CL, Johnson RB (1998) The relationship between concentrations of proinflammatory cytokines within gingiva and the adjacent sulcular depth. J Periodontol 69:865–871PubMed

35.

McManus LM, Marze BT, Schiess AV (1990) Deficiency of salivary PAF in edentulous individuals. J Periodontal Res 25:347–351PubMedCrossRef

36.

Nobuto T, Suwa F, Kono T, Taguchi Y, Takahashi T, Kanemura N, Terada S, Imai H (2005) Microvascular response in the periosteum following mucoperiosteal flap surgery in dogs: angiogenesis and bone resorption and formation. J Periodontol 76:1346–1353PubMedCrossRef

37.

Noguchi K, Morita I, Murota S (1989) The detection of platelet-activating factor in inflamed human gingival tissue. Arch Oral Biol 34:37–41PubMedCrossRef

38.

Nyman S, Lindhe J, Karring T, Rylander H (1982) New attachment following surgical treatment of human periodontal disease. J Clin Periodontol 9:290–296PubMedCrossRef

39.

Okuda K, Tai H, Tanabe K, Suzuki H, Sato T, Kawase T, Saito Y, Wolff LF, Yoshiex H (2005) Platelet-rich plasma combined with a porous hydroxyapatite graft for the treatment of intrabony periodontal defects in humans: a comparative controlled clinical study. J Periodontol 76:890–898PubMedCrossRef

40.

Onodera H, Shibukawa Y, Sugito H, Ota M, Yamada S (2005) Periodontal regeneration in intrabony defects after application of enamel matrix proteins with guided tissue regeneration: an experimental study in dogs. Biomed Res 26:69–77PubMedCrossRef

41.

Park JS, Suh JJ, Choi SH, Moon IS, Cho KS, Kim CK, Chai JK (2001) Effects of pretreatment clinical parameters on bioactive glass implantation in intrabony periodontal defects. J Periodontol 72:730–740PubMedCrossRef

42.

Ramfjord SP, Caffesse RG, Morrison EC, Hill RW, Kerry GJ, Appleberry EA, Nissle RR, Stults DL (1987) Four modalities of periodontal treatment compared over five years. J Periodontal Res 22:222–223PubMedCrossRef

43.

Rasch MS, Mealey BL, Prihoda TJ, Woodard DS, McManus LM (1995) The effect of initial periodontal therapy on salivary platelet-activating factor levels in chronic adult periodontitis. J Periodontol 66:613–623PubMed

44.

Ribaldi E, Guerra M, Mezzasoma AM, Staffolani N, Goracci G, Gresele P (1998) PAF levels in saliva are regulated by inflammatory cells. J Periodontal Res 33:237–241PubMedCrossRef

45.

Rossa C Jr, Marcantonio E Jr, Cirelli JA, Marcantonio RA, Spolidorio LC, Fogo JC (2000) Regeneration of Class III furcation defects with basic fibroblast growth factor (b-FGF) associated with GTR. A descriptive and histometric study in dogs. J Periodontol 71:775–784PubMedCrossRef

46.

Sanz M, Tonetti MS, Zabalegui I, Sicilia A, Blanco J, Rebelo H, Rasperini G, Merli M, Cortellini P, Suvan JE (2004) Treatment of intrabony defects with enamel matrix proteins or barrier membranes: results from a multicenter practice-based clinical trial. J Periodontol 75:726–733PubMedCrossRef

47.

Schmidmaier G, Baehr K, Mohr S, Kretschmar M, Beck S, Wildemann B (2006) Biodegradable polylactide membranes for bone defect coverage: biocompatibility testing, radiological and histological evaluation in a sheep model. Clin Oral Implants Res 17:439–444PubMedCrossRef

48.

Sculean A, Chiantella GC, Windisch P, Arweiler NB, Brecx M, Gera I (2005) Healing of intra-bony defects following treatment with a composite bovine-derived xenograft (Bio-Oss Collagen) in combination with a collagen membrane (Bio-Gide PERIO). J Clin Periodontol 32:720–724PubMedCrossRef

49.

Servillo L, Iorio EL, Quagliuolo L, Camussi G, Balestrieri C, Giovane A (1997) Simultaneous determination of lysophospholipids by high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl 689:281–286PubMedCrossRef

50.

Silness J, Löe H (1964) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 2:121–135CrossRef

51.

Snyder F (1990) Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. Am J Physiol 259(51):697–708

52.

Socransky SS, Haffajee AD (1997) The nature of periodontal disease. Ann Periodontol 2:3–10PubMed

53.

Springer T (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301–314PubMedCrossRef

54.

Stashenko P, Fujiyoshi P, Obernesser MS, Prostak L, Haffajee AD, Socransky SS (1991) Levels of interleukin 1 beta in tissue from sites of active periodontal disease. J Clin Periodontol 18:548–554PubMedCrossRef

55.

Tatakis DN, Trombelli L (1999) Adverse effects associated with a bioabsorbable guided tissue regeneration device in the treatment of human gingival recession defects. A clinicopathologic case report. J Periodontol 70:542–547PubMedCrossRef

56.

Vardar S, Buduneli E, Baylas H, Berdeli AH, Buduneli N, Atilla G (2005) Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on endotoxin-induced periodontitis in rats. J Periodontol 76:99–106PubMedCrossRef

57.

Vardar S, Buduneli E, Turkoglu O, Berdeli AH, Baylas H, Baskesen A, Atilla G (2004) Therapeutic versus prophylactic plus therapeutic administration of omega-3 fatty acid on endotoxin-induced periodontitis in rats. J Periodontol 75:1640–1646PubMedCrossRef

58.

Venable ME, Zimmerman GA, McIntyre TM, Prescott SM (1993) Platelet-activating factor: a phospholipid autacoid with diverse actions. J Lipid Res 34:691–702PubMed

59.

Yuan K, Chen CL, Lin MT (2003) Enamel matrix derivative exhibits angiogenic effect in vitro and in a murine model. J Clin Periodontol 30:732–738PubMedCrossRef

60.

Zheng ZG, Wood DA, Sims SM, Dixon SJ (1993) Platelet-activating factor stimulates resorption by rabbit osteoclasts in vitro. Am J Physiol 264(1 Pt 1):74–81

Title: Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery
Authors: Gonca Cayir Keles
Burcu Ozkan Cetinkaya
Bulent Ayas
Ibrahim Isildak
Emine Diraman
Hulya Koprulu
Gokhan Acikgoz
Publication date: 01-12-2007
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 4/2007
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-007-0123-2

2024 ASCO Annual Meeting

Springer Medicine

Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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