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01-04-2023 | Brief Report

Genome characterisation of norovirus GII.P17-GII.17 detected during a large gastroenteritis outbreak in Romania in 2021

Authors: Sorin Dinu, Mihaela Oprea, Ramona-Ionela Iordache, Lavinia-Cipriana Rusu, Codruța-Romanița Usein

Published in: Archives of Virology | Issue 4/2023

Abstract

Norovirus (NoV) is one of the leading causes of acute gastroenteritis worldwide. Genotype GII.P17-G.II.17 emerged in Asia between 2013 and 2015 and transiently replaced the GII.4 Sydney 2012 variant circulating at that time. We present the genome characterisation of a GII.P17-GII.17 strain causing a large outbreak in Romania in 2021. Our study shows that the 2021 strain belongs to a novel cluster of genotype GII.17, different from the two previously recognised P.17 clusters. Distinctive substitutions in predicted conformational epitopes of VP1 were identified for this new cluster. Also, our phylogenetic analysis showed the existence of another P.17 cluster grouping strains from France and Canada.

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Title: Genome characterisation of norovirus GII.P17-GII.17 detected during a large gastroenteritis outbreak in Romania in 2021
Authors: Sorin Dinu
Mihaela Oprea
Ramona-Ionela Iordache
Lavinia-Cipriana Rusu
Codruța-Romanița Usein
Publication date: 01-04-2023
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 4/2023
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-023-05741-6

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