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01-01-2021 | Rhinovirus | Brief Report

Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution

Authors: Kim Tien Ng, Yutaka Takebe, Adeeba Kamarulzaman, Kok Keng Tee

Published in: Archives of Virology | Issue 1/2021

Abstract

Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique “clade-defining” substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5ʹ-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.

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Title: Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
Authors: Kim Tien Ng
Yutaka Takebe
Adeeba Kamarulzaman
Kok Keng Tee
Publication date: 01-01-2021
Publisher: Springer Vienna
Keyword: Rhinovirus
Published in: Archives of Virology / Issue 1/2021
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-020-04855-5

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