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Archives of Virology
Published in: Archives of Virology 4/2013

01-04-2013 | Original Article

The emergence of HIV-1 primary drug resistance genotypes among treatment-naïve men who have sex with men in high-prevalence areas in China

Authors: Juan Yang, Hui Xing, Jianli Niu, Lingjie Liao, Yuhua Ruan, Xiang He, Yi Feng, Zhe Li, Yiming Shao

Published in: Archives of Virology | Issue 4/2013

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Abstract

The prevalence of HIV-1 infection in men who have sex with men (MSM) in China has drastically increased, and circulating strains may have acquired transmitted drug resistance (TDR). We determined TDR genotypes among antiretroviral therapy (ART)-naïve MSM in 19 provinces/cities where HIV-1 prevalence among MSM is high, and found an overall 4.9 % TDR rate. Although protease inhibitors (PI) were not in the first-line antiretroviral drug list provided through the National ART Program, 70.4 % of the detected TDR belongs to this category. Our findings confirm the urgent need for TDR surveillance in order to optimize treatment effects of the National ART Program.
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Metadata
Title
The emergence of HIV-1 primary drug resistance genotypes among treatment-naïve men who have sex with men in high-prevalence areas in China
Authors
Juan Yang
Hui Xing
Jianli Niu
Lingjie Liao
Yuhua Ruan
Xiang He
Yi Feng
Zhe Li
Yiming Shao
Publication date
01-04-2013
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 4/2013
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-012-1557-7

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