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Archives of Virology
Published in: Archives of Virology 9/2010

01-09-2010 | Original Article

Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71

Authors: Cyril C. Y. Yip, Susanna K. P. Lau, Boping Zhou, Ming-Xia Zhang, Hoi-Wah Tsoi, Kwok-Hung Chan, Xin-Chun Chen, Patrick C. Y. Woo, Kwok-Yung Yuen

Published in: Archives of Virology | Issue 9/2010

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Abstract

Hand–foot–mouth disease due to enterovirus 71 (EV71) and coxsackievirus A16 (CA16) has recently caused large outbreaks in mainland China in 2008. We performed complete genome sequencing on two EV71 (SZ/HK08-5 and SZ/HK08-6) and two CA16 (SZ/HK08-3 and SZ/HK08-7) strains from patients in Shenzhen, China. Phylogenetic, similarity plot and bootscan analyses revealed recombination between EV71 genotypes B and C at the 2A–2B junction, and between EV71 genotype B and CA16 strain G-10 in the 3C region for EV71 strains. A similar phenomenon was also found upon further gene sequencing with other EV71 strains. Recombination between CA16 strain G-10 and EV71 genotype A at the 2A–2B junction was also observed for CA16 strains. The present “double-recombinant” EV71 strains circulating in China and other EV71 subgenotype “C4” strains represent an additional genotype, D. CA16 strains should also be classified into two genotypes. This represents the first evidence for a combination of intratypic and intertypic recombination in EV71 strains.
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Metadata
Title
Emergence of enterovirus 71 “double-recombinant” strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
Authors
Cyril C. Y. Yip
Susanna K. P. Lau
Boping Zhou
Ming-Xia Zhang
Hoi-Wah Tsoi
Kwok-Hung Chan
Xin-Chun Chen
Patrick C. Y. Woo
Kwok-Yung Yuen
Publication date
01-09-2010
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 9/2010
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-010-0722-0

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