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Archives of Virology
Published in: Archives of Virology 7/2009

01-07-2009 | Original Article

A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: identification of two novel subgenotypes, B8 and C7

Authors: Mulyanto, Sulaiman Ngongu Depamede, Kiely Surayah, Fumio Tsuda, Koji Ichiyama, Masaharu Takahashi, Hiroaki Okamoto

Published in: Archives of Virology | Issue 7/2009

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Abstract

Upon phylogenetic analysis of a partial S gene sequence [396 nucleotides (nt)], 928 hepatitis B virus (HBV) strains obtained from 899 viremic subjects in 28 major cities on 15 islands of Indonesia in 1989–2007 segregated into four HBV genotypes. Genotype B was predominant (66%), followed by genotype C (26%), genotype D (7%), and genotype A (0.8%). Comparative and phylogenetic analyses of the 396-nt S gene sequence of 928 HBV isolates and whole genomic sequences of 25 selected HBV isolates revealed a total of 14 subgenotypes within genotypes A–D: two (A1 and A2) in genotype A (HBV/A), five (B2, B3, B5, B7, and a novel subgenotype, tentatively designated B8) in HBV/B, five (C1, C2, C5, C6, and another novel subgenotype, C7) in HBV/C, and two (D1 and D3) in HBV/D. The distribution of HBV genotypes/subgenotypes, including B8 and C7, seems to be associated with ethnological origins in Indonesia.
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Metadata
Title
A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: identification of two novel subgenotypes, B8 and C7
Authors
Mulyanto
Sulaiman Ngongu Depamede
Kiely Surayah
Fumio Tsuda
Koji Ichiyama
Masaharu Takahashi
Hiroaki Okamoto
Publication date
01-07-2009
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 7/2009
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-009-0406-9

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