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01-08-2015 | Neurology and Preclinical Neurological Studies - Original Article

Cutaneous autonomic denervation in Parkinson’s disease

Authors: Judith Navarro-Otano, Jordi Casanova-Mollà, Merche Morales, Josep Valls-Solé, Eduard Tolosa

Published in: Journal of Neural Transmission | Issue 8/2015

Abstract

Numerous studies have detailed involvement of the peripheral autonomic nervous system (PANS) in Parkinson’s disease (PD). We assessed autonomic innervation of dermal annexes through quantitative fluorescence measurement from skin obtained via punch biopsies at distal leg region in PD and control subjects. We defined a ratio between the area corresponding to protein gen product (PGP) immunoreactivity and the area corresponding to blood vessel or sweat gland as a quantitative measure of autonomic innervation. Presence of alpha-synuclein (AS) deposits in dermis and hypodermis was also assessed by immunohistochemistry. Skin biopsies form six PD patients and six healthy controls were studied. Autonomic innervation scores were lower in PD than in controls in both blood vessels and sweat glands. No AS or phosphorylated AS (pAS) immunoreactivity was detected in dermis or hypodermis in any of the studied subjects. The results of this investigation suggest that autonomic innervation of dermal annexes in living patients with PD is reduced compared to controls. AS or pAS deposits were not found in dermis or hypodermis suggesting that distal leg skin study is not useful for in vivo detection of AS in PD.

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Title: Cutaneous autonomic denervation in Parkinson’s disease
Authors: Judith Navarro-Otano
Jordi Casanova-Mollà
Merche Morales
Josep Valls-Solé
Eduard Tolosa
Publication date: 01-08-2015
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 8/2015
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-014-1355-3

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Cutaneous autonomic denervation in Parkinson’s disease

Abstract

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