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01-08-2015 | Psychiatry and Preclinical Psychiatric Studies - Review article

The potential of biomarkers in psychiatry: focus on proteomics

Authors: Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Johannes Thome, Costel C. Darie, Alisa G. Woods

Published in: Journal of Neural Transmission | Special Issue 1/2015

Abstract

The etiology and pathogenesis of many psychiatric disorders are unclear with many signaling pathways and complex interactions still unknown. Primary information provided from gene expression or brain activity imaging experiments is useful, but can have limitations. There is a current effort focusing on the discovery of diagnostic and prognostic proteomic potential biomarkers for psychiatric disorders. Despite this work, there is still no biological diagnostic test available for any mental disorder. Biomarkers may advance the care of psychiatric illnesses and have great potential to knowledge of psychiatric disorders but several drawbacks must be considered. Here, we describe the potential of proteomic biomarkers for better understanding and diagnosis of psychiatric disorders and current putative biomarkers for schizophrenia, depression, autism spectrum disorder and attention deficit/hyperactivity disorder.

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Title: The potential of biomarkers in psychiatry: focus on proteomics
Authors: Izabela Sokolowska
Armand G. Ngounou Wetie
Kelly Wormwood
Johannes Thome
Costel C. Darie
Alisa G. Woods
Publication date: 01-08-2015
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue Special Issue 1/2015
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1134-6

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The potential of biomarkers in psychiatry: focus on proteomics

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