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01-08-2015 | Psychiatry and Preclinical Psychiatric Studies - Review article

Novel putative mechanisms to link circadian clocks to healthy aging

Authors: Aurel Popa-Wagner, Bogdan Catalin, Ana-Maria Buga

Published in: Journal of Neural Transmission | Special Issue 1/2015

Abstract

The circadian clock coordinates the internal physiology to increase the homeostatic capacity thereby providing both a survival advantage to the system and an optimization of energy budgeting. Multiple-oscillator circadian mechanisms are likely to play a role in regulating human health and may contribute to the aging process. Our aim is to give an overview of how the central clock in the hypothalamus and peripheral clocks relate to aging and metabolic disorders, including hyperlipidemia and hyperglycemia. In particular, we unravel novel putative mechanisms to link circadian clocks to healthy aging. This review may lead to the design of large-scale interventions to help people stay healthy as they age by adjusting daily activities, such as feeding behavior, and or adaptation to age-related changes in individual circadian rhythms.

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Title: Novel putative mechanisms to link circadian clocks to healthy aging
Authors: Aurel Popa-Wagner
Bogdan Catalin
Ana-Maria Buga
Publication date: 01-08-2015
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue Special Issue 1/2015
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1128-4

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Novel putative mechanisms to link circadian clocks to healthy aging

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