Published in:
27-01-2023 | Colorectal Cancer | Original Article
The T-CEA score: a useful prognostic indicator based on postoperative CEA and pathological T4 levels for patients with stage II–III colorectal cancer
Authors:
Hiromichi Sonoda, Takeshi Yamada, Akihisa Matsuda, Yasuyuki Yokoyama, Ryo Ohta, Seiichi Shinji, Kazuhide Yonaga, Takuma Iwai, Kohki Takeda, Koji Ueda, Sho Kuriyama, Toshimitsu Miyasaka, Shintaro Kanaka, Nobuhiko Taniai, Hiroshi Yoshida
Published in:
Surgery Today
|
Issue 8/2023
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Abstract
Purpose
To investigate a prognostic score for stage II–III colorectal cancer (CRC) based on post-CEA and pT4 levels.
Methods
Two cohorts of stage II–III CRC patients who underwent curative surgery between 2011 and 2017 were included. The prognostic score (T-CEA score) was calculated as follows: T-CEA-0, post-CEA ≤ 5 ng/mL and pT1–3; T-CEA-1, post-CEA > 5 ng/mL or pT4; T-CEA-2, post-CEA > 5 ng/mL and pT4.
Results
The T-CEA scores of the 587 patients were as follows: T-CEA-0 (n = 436; 74%), T-CEA-1 (n = 129; 22%), and T-CEA-2 (n = 10; 2%). The 5-year recurrence-free survival (RFS) rates of the T-CEA-0, 1, and 2 groups were 80.3%, 54.8%, and 0%, respectively (P < 0.01), and the 5-year overall survival (OS) rates were 90.9%, 74.2%, and 0%, respectively (T-CEA-0 vs T-CEA-1: P < 0.01, T-CEA-1 vs T-CEA-2: P = 0.04). Multivariate analysis revealed that an elevated T-CEA score of 1 or 2 was a significant risk factor for poor RFS (HR: 2.89, P < 0.01) and OS (HR: 2.85, P < 0.01).
Conclusion
The T-CEA score is a reliable and convenient prognostic score for stage II–III CRC.