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Surgery Today
Published in: Surgery Today 10/2013

01-10-2013 | Review Article

Novel therapy for liver regeneration by increasing the number of platelets

Authors: Kazuhiro Takahashi, Soichiro Murata, Nobuhiro Ohkohchi

Published in: Surgery Today | Issue 10/2013

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Abstract

Platelets are the smallest blood constitutes which contain three types of granules; alpha granules, dense granules, and lysosomal granules. Each granule contains various biophysiological substances such as growth factors, cytokines, etc. Platelets have been conventionally viewed as a trigger of inflammatory responses and injury in the liver. Some studies revealed that platelets have strong effects on promoting liver regeneration. This review presents experimental evidence of platelets in accelerating liver regeneration and describes three different mechanisms involved; (1) the direct effect on hepatocytes, where platelets translocate to the space of Disse and release growth factors through direct contact with hepatocytes, (2) the cooperative effect with liver sinusoidal endothelial cells, where the dense concentration of sphingosine-1-phosphate in platelets induces excretion of interleukin-6 from liver sinusoidal endothelial cells, and (3) the collaborative effect with Kupffer cells, where the functions of Kupffer cells are enhanced by platelets.
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Metadata
Title
Novel therapy for liver regeneration by increasing the number of platelets
Authors
Kazuhiro Takahashi
Soichiro Murata
Nobuhiro Ohkohchi
Publication date
01-10-2013
Publisher
Springer Japan
Published in
Surgery Today / Issue 10/2013
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-012-0418-z

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