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01-04-2013 | Case Report

Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case

Authors: Mikihiro Kohno, Ken Shirabe, Yohei Mano, Jun Muto, Takashi Motomura, Kazuki Takeishi, Takeo Toshima, Masanori Yoshimatsu, Hideki Ijichi, Noboru Harada, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara

Published in: Surgery Today | Issue 4/2013

Abstract

This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had marked granulocytosis and his serum level of G-CSF was elevated. Complete tumor resection was performed, and the pathological assessment of the resected specimen revealed HCC with extensive sarcomatous changes and immunohistochemical staining for G-CSF and G-CSF receptor. Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor.

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Title: Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case
Authors: Mikihiro Kohno
Ken Shirabe
Yohei Mano
Jun Muto
Takashi Motomura
Kazuki Takeishi
Takeo Toshima
Masanori Yoshimatsu
Hideki Ijichi
Noboru Harada
Shinichi Aishima
Hideaki Uchiyama
Tomoharu Yoshizumi
Akinobu Taketomi
Yoshihiko Maehara
Publication date: 01-04-2013
Publisher: Springer Japan
Published in: Surgery Today / Issue 4/2013
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-012-0202-0

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Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case

Abstract

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Abstract

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