Top

Published in:

01-07-2008 | Original Article

Cerebral glucose metabolic abnormality in patients with congenital scoliosis

Authors: Weon Wook Park, Kuen Tak Suh, Jeung Il Kim, Ja Gyung Ku, Hong Seok Lee, Seong-Jang Kim, In-Ju Kim, Yong-Ki Kim, Jung Sub Lee

Published in: European Spine Journal | Issue 7/2008

Abstract

A possible association between congenital scoliosis and low mental status has been recognized, but there are no reports describing the mental status or cerebral metabolism in patients with congenital scoliosis in detail. We investigated the mental status using a mini-mental status exam as well as the cerebral glucose metabolism using F-18 fluorodeoxyglucose brain positron emission tomography in 12 patients with congenital scoliosis and compared them with those of 14 age-matched patients with adolescent idiopathic scoliosis. The mean mini-mental status exam score in the congenital scoliosis group was significantly lower than that in the adolescent idiopathic scoliosis group. Group analysis found that various brain areas of patients with congenital scoliosis showed glucose hypometabolisms in the left prefrontal cortex (Brodmann area 10), right orbitofrontal cortex (Brodmann area 11), left dorsolateral prefrontal cortex (Brodmann area 9), left anterior cingulate gyrus (Brodmann area 24) and pulvinar of the left thalamus. From this study, we could find the metabolic abnormalities of brain in patients with congenital scoliosis and suggest the possible role of voxel-based analysis of brain fluorodeoxyglucose positron emission tomography.

Alsop DC, Detre JA, Grossman M (2000) Assessment of cerebral blood flow in Alzheimer’s disease by spin-labeled magnetic resonance imaging. Ann Neurol 47:93–100PubMedCrossRef

Basu PS, Elsebaie H, Noordeen MH (2002) Congenital spinal deformity: a comprehensive assessment at presentation. Spine 27:2255–2259PubMedCrossRef

Bradford DS, Heithoff KB, Cohen M (1991) Intraspinal abnormalities and congenital spine deformities: a radiographic and MRI study. J Pediatr Orthop 11:36–41PubMed

Bush G, Luu P, Posner MI (2000) Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4:215–222PubMedCrossRef

Chiron C, Raynaud C, Maziere B, Zilbovicius M, Laflamme L, Masure MC, Dulac O, Bourguignon M (1992) Changes in regional cerebral blood flow during brain maturation in children and adolescents. J Nucl Med 33:696–703PubMed

Conner AN, Young DG, Hide TA (1984) Occult intraspinal anomalies and congenital scoliosis. J Bone Joint Surg 66:1319PubMed

Devinsky O, Morrell MJ, Vogt BA (1995) Contributions of anterior cingulate cortex to behaviour. Brain 118:279–306PubMedCrossRef

Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, Schwaiger M, Kurz A (2003) Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer’s disease: a PET follow-up study. Eur J Nucl Med Mol Imaging 30:1104–1113PubMedCrossRef

Eidelberg D, Moeller JR, Dhawan V, Sidtis JJ, Ginos JZ, Strother SC, Cedarbaum J, Greene P, Fahn S, Rottenberg DA (1990) The metabolic anatomy of Parkinson’s disease: complementary [18F]fluorodeoxyglucose and [18F]fluorodopa positron emission tomographic studies. Mov Disord 5:203–213PubMedCrossRef

10.

Foster NL, Chase TN, Mansi L, Brooks R, Fedio P, Patronas NJ, Di Chiro G (1984) Cortical abnormalities in Alzheimer’s disease. Ann Neurol 16:649–654PubMedCrossRef

11.

Gillespie R, Faithfull DK, Roth A, Hall JE (1973) Intraspinal anomalies in congenital scoliosis. Clin Orthop Relat Res 93:103–109PubMedCrossRef

12.

Hirono N, Mori E, Ishii K, Ikejiri Y, Imamura T, Shimomura T, Hashimoto M, yamashita H, Sasaki M (1998) Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 64:552–554PubMedCrossRef

13.

Jeong SK, Cho KH, Kim JM (2004) The usefulness of the Korean version of modified mini-mental state examination (K-mMMSE) for dementia screening in community dwelling elderly people. BMC Public Health 4:31PubMedCrossRef

14.

Johnson KA, Jones K, Holman BL, Becker JA, Spiers PA, Satlin A, Albert MS (1998) Preclinical prediction of Alzheimer’s disease using SPECT. Neurology 50:1563–1571PubMed

15.

Lee JD, Kim DI, Ryu YH, Whang GJ, Park CI, Kim DG (1998) Technetium-99m-ECD brain SPECT in cerebral palsy: comparison with MRI. J Nucl Med 39:619–623PubMed

16.

Lee CK, Chang BS, Hong YM, Yang SW, Lee CS, Seo JB (2001) Spinal deformities in Noonan syndrome: a clinical review of sixty cases. J Bone Joint Surg 83-A:1495–1502PubMed

17.

Lee BF, Yang P, Jong YJ, Hsu HY, Chen CC (2002) Single photon emission computerized tomography in children with developmental language disorder-a preliminary report. Kaohsiung J Med Sci 18:373–378PubMed

18.

MacEwen GD, Winter RB, Hardy JH (1972) Evaluation of kidney anomalies in congenital scoliosis. J Bone Joint Surg 54-A:1451–1454

19.

Pandya DN, Van Hoesen GW, Mesulam MM (1981) Efferent connections of the cingulate gyrus in the rhesus monkey. Exp Brain Res 42:319–330PubMedCrossRef

20.

Rubinstein M, Denays R, Ham HR, Piepsz A, VanPachterbeke T, Haumont D, Noel P (1989) Functional imaging of brain maturation in humans using iodine-123 iodoamphetamine and SPECT. J Nucl Med 30:1982–1985PubMed

21.

Suh KT, Lee SS, Kim SJ, Kim YK, Lee JS (2007) Pineal gland metabolism in patients with adolescent idiopathic scoliosis. J Bone Joint Surg 89-B:66–71CrossRef

22.

Sutherland RJ, Whishaw IQ, Kolb B (1988) Contributions of cingulate cortex to two forms of spatial learning and memory. J Neurosci 8:1863–1872PubMed

23.

Vogt BA, Finch DM, Olson CR (1992) Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex 2:435–443PubMed

24.

Whalen PJ, Bush G, McNally RJ, Wilhelm S, McInerney SC, Jenike MA, Rauch SL (1998) The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division. Biol Psychiatry 44:1219–1228PubMedCrossRef

25.

Willis MW, Ketter TA, Kimbrell TA, George MS, Herscovitch P, Danielson AL, Benson BE, Post RM (2002) Age, sex and laterality effects on cerebral glucose metabolism in healthy adults. Psychiatry Res 114:23–37PubMedCrossRef

26.

Winter RB, Haven JJ, Moe JH, Lagaard SM (1974) Diastematomyelia and congenital spine deformities. J Bone Joint Surg 56-A:27–39

Title: Cerebral glucose metabolic abnormality in patients with congenital scoliosis
Authors: Weon Wook Park
Kuen Tak Suh
Jeung Il Kim
Ja Gyung Ku
Hong Seok Lee
Seong-Jang Kim
In-Ju Kim
Yong-Ki Kim
Jung Sub Lee
Publication date: 01-07-2008
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue 7/2008
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-008-0682-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cerebral glucose metabolic abnormality in patients with congenital scoliosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 7/2008

Clinimetric evaluation of active range of motion measures in patients with non-specific neck pain: a systematic review

Psychometric properties of a German version of the neck pain and disability scale

Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients

Effect of long-term axial spinal unloading on vertebral body height in adult thoracolumbar spine

Neither the WAD-classification nor the Quebec Task Force follow-up regimen seems to be important for the outcome after a whiplash injury. A prospective study on 186 consecutive patients

Imperfect placebos are common in low back pain trials: a systematic review of the literature