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Journal of Gastroenterology
Published in: Journal of Gastroenterology 2/2016

01-02-2016 | Letter to the Editor

Reply to the letter by Kawada entitled ‘‘Combined effect of proton-pump inhibitors and other drugs with regard to lower gastrointestinal tract bleeding with special reference to low-dose aspirin’’

Authors: Naoyoshi Nagata, Takuro Shimbo

Published in: Journal of Gastroenterology | Issue 2/2016

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Excerpt

We thank Tomoyuki Kawada for his interest in our article that examined the effects of proton-pump inhibitors (PPIs) with regard to the risk of acute lower gastrointestinal tract bleeding and the effects of their interactions with nonsteroidal anti-inflammatory drugs (NSAIDs), low-dose aspirin, clopidogrel, and warfarin with regard to the risk of lower gastrointestinal tract bleeding [1]. Kawada highlighted three limitations in our study. …
Literature
1.
Nagata N, Niikura R, Aoki T, et al. Effect of proton-pump inhibitors on the risk of lower gastrointestinal bleeding associated with NSAIDs, aspirin, clopidogrel, and warfarin. J Gastroenterol. 2015. doi:10.​1007/​s00535-015-1055-2.
2.
Miyake K, Akimoto T, Hanada Y, et al. Proton pump inhibitors are associated with lower gastrointestinal tract bleeding in low-dose aspirin users with ischaemic heart disease. Dig Liver Dis. 2015;47:757–62.CrossRefPubMed
3.
Nagata N, Niikura R, Aoki T, et al. Lower GI bleeding risk of nonsteroidal anti-inflammatory drugs and antiplatelet drug use alone and the effect of combined therapy. Gastrointest Endosc. 2014;80:1124–31.CrossRefPubMed
4.
Nagata N, Niikura R, Sekine K, et al. Risk of peptic ulcer bleeding associated with helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study. J Gastroenterol Hepatol. 2015;30:292–8.CrossRefPubMed
5.
Williams C, McColl KE. Review article: proton pump inhibitors and bacterial overgrowth. Aliment Pharmacol Ther. 2006;23:3–10.CrossRefPubMed
6.
Lombardo L, Foti M, Ruggia O, et al. Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy. Clin Gastroenterol Hepatol. 2010;8:504–8.CrossRefPubMed
7.
Wallace JL, Syer S, Denou E, et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology. 2011;141:1314–22.CrossRefPubMed
Metadata
Title
Reply to the letter by Kawada entitled ‘‘Combined effect of proton-pump inhibitors and other drugs with regard to lower gastrointestinal tract bleeding with special reference to low-dose aspirin’’
Authors
Naoyoshi Nagata
Takuro Shimbo
Publication date
01-02-2016
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 2/2016
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-015-1139-z

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Keynote webinar | Spotlight on medication adherence

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