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Journal of Gastroenterology
Published in: Journal of Gastroenterology 6/2014

01-06-2014 | Review

Surgical outcomes for 131 cases of carcinosarcoma of the hepatobiliary tract

Authors: Takehiro Okabayashi, Yasuo Shima, Jun Iwata, Tatsuo Iiyama, Tatsuaki Sumiyoshi, Akihito Kozuki, Teppei Tokumaru, Yasuhiro Hata, Yoshihiro Noda, Masanori Morita

Published in: Journal of Gastroenterology | Issue 6/2014

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Abstract

Carcinosarcoma of the hepatobiliary tract is highly aggressive and has a poor prognosis even after curative resection. The purpose of this study was to collate and analyze published data to clarify the surgical outcome of carcinosarcoma of the hepatobiliary tract and the relationships between potential prognostic factors and survival after surgery. We surveyed worldwide literature from 1970 to 2012 and obtained clinicopathological data for 131 patients who had undergone surgical resection for carcinosarcoma of the hepatobiliary tract, including one patient from our clinic. The relationships between potential prognostic factors and survival rates were examined using the Kaplan–Meier method and the log-rank test. The overall 1-, 3-, and 5-year survival rates for patients with carcinosarcoma of the hepatobiliary tract after surgery were 44.0, 29.3, and 27.0 %, respectively. In univariate analyses, age and gender were not significant prognostic factors; however, advanced stage according to the classification of the Union for International Cancer Control in resected specimens was significantly associated with a shorter survival time after surgery. Although carcinosarcoma of the hepatobiliary tract remains a rare disease worldwide, its poor prognosis, even after curative resection, demands further epidemiological and pathological study that could lead to the development of new management strategies.
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Metadata
Title
Surgical outcomes for 131 cases of carcinosarcoma of the hepatobiliary tract
Authors
Takehiro Okabayashi
Yasuo Shima
Jun Iwata
Tatsuo Iiyama
Tatsuaki Sumiyoshi
Akihito Kozuki
Teppei Tokumaru
Yasuhiro Hata
Yoshihiro Noda
Masanori Morita
Publication date
01-06-2014
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 6/2014
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-013-0882-2

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The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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