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Published in: Journal of Gastroenterology 6/2014

01-06-2014 | Original Article—Alimentary Tract

Prognostic significance of the modified Glasgow prognostic score in elderly patients with gastric cancer

Authors: Kotaro Hirashima, Masayuki Watanabe, Hironobu Shigaki, Yu Imamura, Satoshi Ida, Masaaki Iwatsuki, Takatsugu Ishimoto, Shiro Iwagami, Yoshifumi Baba, Hideo Baba

Published in: Journal of Gastroenterology | Issue 6/2014

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Abstract

Background

The Glasgow prognostic score (GPS) is a preoperatively determined inflammation-based score. Reports suggest a significant correlation between the GPS and prognosis in several cancer types. We aimed to clarify the prognostic significance of the modified GPS (mGPS) in patients undergoing gastrectomy for gastric cancer.

Methods

Two hundred and ninety-four patients with gastric cancer, 195 aged < 75 years (group NE) and 99 aged > 75 years (group E), who underwent gastrectomy from March 2005 to March 2011 were enrolled. Patients with an elevated C-reactive protein level (> 0.5 mg/dL) and hypoalbuminemia (< 3.8 g/dL) were assigned a mGPS of 2, those with either 1 abnormality were assigned a mGPS of 1, and those with neither abnormality were assigned a mGPS of 0. Cox proportional hazard models and Kaplan–Meier analysis were used to evaluate the usefulness of mGPS as a prognostic indicator.

Results

In the NE group, the prognosis of the 3 groups stratified by mGPS did not differ significantly. In multivariate Cox regression analysis, the type of gastrectomy, peritoneal metastasis, and stage were independently associated with poor prognosis. However, group E patients with a mGPS of 2 had significantly poorer prognosis than those with a mGPS of 0 or 1. In this age group, stage and mGPS were independently associated with poor prognosis.

Conclusions

In patients aged > 75 years undergoing potentially curative gastrectomy, the preoperative mGPS was an independent predictor of survival. Therefore, mGPS can be a useful prognostic indicator in elderly patients with gastric cancer.
Appendix
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Metadata
Title
Prognostic significance of the modified Glasgow prognostic score in elderly patients with gastric cancer
Authors
Kotaro Hirashima
Masayuki Watanabe
Hironobu Shigaki
Yu Imamura
Satoshi Ida
Masaaki Iwatsuki
Takatsugu Ishimoto
Shiro Iwagami
Yoshifumi Baba
Hideo Baba
Publication date
01-06-2014
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 6/2014
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-013-0855-5

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