Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Supportive Care in Cancer
Published in: Supportive Care in Cancer 1/2024

01-01-2024 | Stem Cell Transplantation | Review

Nutritional status and body mass index before hematopoietic stem cell transplantation (HSCT) and associated outcomes: a rapid review

Authors: Rachel Sauls, Acadia W. Buro, Lindsey Montgomery, Marilyn Stern, Farhad Khimani, Sylvia L. Crowder

Published in: Supportive Care in Cancer | Issue 1/2024

Login to get access

Abstract

Purpose

Hematopoietic stem cell transplantation (HSCT) recipients experience several post-HSCT complications affecting nutritional status, body mass index (BMI), and mortality that can potentially be mitigated by nutritional management. This rapid review examines the relationship between pre-HSCT nutritional status and BMI and post-HSCT survival.

Methods

Articles were identified from PubMed, Scopus, and Embase. Two researchers independently completed the title, abstract, and full-text review. Inclusion criteria included the following: (1) randomized clinical trials or observational studies; (2) human subjects diagnosed with cancer and undergoing HSCT; (3) reported pre-HSCT nutritional status (e.g., diet recall, nutritional survey, dietitian session) or BMI; and (4) reported treatment related mortality and/or survival.

Results

The initial search found 3036 articles, 28 were included in full-text review, and 18 met inclusion criteria. Articles had quasi-experimental (n = 2) and observational (n = 16) study designs. Of the studies, n = 5 reported nutritional intake decreased post-HSCT, and n = 2 reported nutrition intervention (i.e., controlled feeding) post-HSCT improved survival. Four studies reported having a BMI classified as underweight improved survival, while n = 5 reported having a BMI classified as overweight or obese improved survival.

Conclusion

Current research exploring the relationship between nutritional status and BMI with HSCT survival is mixed. Further research is needed to determine how nutritional status and BMI are associated withsurvival post-HSCT to inform future intervention work.
Appendix
Available only for authorised users
Literature
1.
Jessop H et al (2019) General information for patients and carers considering haematopoietic stem cell transplantation (HSCT) for severe autoimmune diseases (ADs): a position statement from the EBMT Autoimmune Diseases Working Party (ADWP), the EBMT Nurses Group, the EBMT Patient, Family and Donor Committee and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Bone Marrow Transplant 54(7):933–942PubMedPubMedCentral
2.
Burt RK et al (2006) Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens. Arthritis Rheum 54(12):3750–3760PubMed
3.
Ryan AM et al (2019) Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival. Nutrition 67-68:110539PubMed
4.
Coa KI et al (2015) The impact of cancer treatment on the diets and food preferences of patients receiving outpatient treatment. Nutr Cancer 67(2):339–353PubMedPubMedCentral
5.
Fuji S et al (2015) Severe weight loss in 3 months after allogeneic hematopoietic SCT was associated with an increased risk of subsequent non-relapse mortality. Bone Marrow Transplant 50(1):100–105PubMed
6.
7.
Crowder SL et al (2018) Nutrition impact symptoms and associated outcomes in post-chemoradiotherapy head and neck cancer survivors: a systematic review. J Cancer Surviv 12(4):479–494PubMed
8.
Koterazawa Y et al (2020) Severe weight loss after minimally invasive oesophagectomy is associated with poor survival in patients with oesophageal cancer at 5 years. BMC Gastroenterol 20(1):407PubMedPubMedCentral
9.
10.
Afessa B, Peters SG (2006) Major complications following hematopoietic stem cell transplantation. Semin Respir Crit Care Med 27(3):297–309PubMed
11.
Rieger CT et al (2015) Weight loss and decrease of body mass index during allogeneic stem cell transplantation are common events with limited clinical impact. PLoS One 10(12):e0145445PubMedPubMedCentral
12.
13.
Botti S et al (2015) Nutritional support in patients undergoing haematopoietic stem cell transplantation: a multicentre survey of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) transplant programmes. Ecancermedicalscience 9:545PubMedPubMedCentral
14.
Muscaritoli M et al (2021) ESPEN practical guideline: clinical nutrition in cancer. Clin Nutr 40(5):2898–2913PubMed
15.
Evans JC, Hirani SP, Needle JJ (2019) Nutritional and post-transplantation outcomes of enteral versus parenteral nutrition in pediatric hematopoietic stem cell transplantation: a systematic review of randomized and nonrandomized studies. Biol Blood Marrow Transplant 25(8):e252–e259PubMed
16.
Akbulut G, Yesildemir O (2021) Overview of nutritional approach in hematopoietic stem cell transplantation: COVID-19 update. World J Stem Cells 13(10):1530–1548PubMedPubMedCentral
17.
Crowder SL et al (2019) Head and neck cancer survivors’ preferences for and evaluations of a post-treatment dietary intervention. Nutr J 18(1):57PubMedPubMedCentral
18.
Garritty C et al (2021) Cochrane Rapid Reviews Methods Group offers evidence-informed guidance to conduct rapid reviews. J Clin Epidemiol 130:13–22PubMed
19.
Garritty C et al (2020) Assessing how information is packaged in rapid reviews for policy-makers and other stakeholders: a cross-sectional study. Health Res Policy Syst 18(1):112PubMedPubMedCentral
20.
Araie H et al (2019) Prediction of clinical outcome by controlling nutritional status (CONUT) before allogeneic hematopoietic stem cell transplantation in myeloid malignancies. Int J Hematol 110(5):599–605PubMed
21.
Baumgartner A et al (2016) Association of nutritional parameters with clinical outcomes in patients with acute myeloid leukemia undergoing haematopoietic stem cell transplantation. Ann Nutr Metab 69:89PubMed
22.
Brauer D et al (2021) Nutritional status at diagnosis and pre-transplant weight loss impact outcomes of acute myeloid leukemia patients following allogeneic stem cell transplantation. Hemasphere 5(3):e532PubMedPubMedCentral
23.
Brotelle T et al (2018) Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation. Clin Nutr 37(2):739–745PubMed
24.
25.
Doney K et al (2019) Impact of body mass index on outcomes of hematopoietic stem cell transplantation in adults. Biol Blood Marrow Transplant 25(3):613–620PubMed
26.
El-Ghammaz AMS et al (2017) Nutritional status of allogeneic hematopoietic stem cell transplantation recipients: influencing risk factors and impact on survival. Support Care Cancer 25(10):3085–3093PubMed
27.
Ferreira EE et al (2014) Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study. Rev Bras Hematol Hemoter 36(6):414–419PubMedPubMedCentral
28.
Kerby EH et al (2018) Nutritional risk factors predict severe acute graft-versus-host disease and early mortality in pediatric allogeneic hematopoietic stem cell transplantation. Pediatr Blood Cancer 65(2):26853. https://​doi.​org/​10.​1002/​pbc.​26853
29.
Koch LOM et al (2022) Influence of body composition assessed by computed tomography on mortality in older adults undergoing hematopoietic stem cell transplantation. Nutr Clin Pract 37(6):1400–1408PubMed
30.
Kranjčec I et al (2020) Nutritional status as a predictor of adverse events and survival in pediatric autologous stem cell transplant. Pediatr Hematol Oncol 37(8):717–731PubMed
31.
Tamaki M et al (2021) Body weight loss before allogeneic hematopoietic stem cell transplantation predicts survival outcomes in acute leukemia patients. Transpl Cellul Ther 27(4):340.e1–340.e6
32.
White M et al (2012) Survival in overweight and underweight children undergoing hematopoietic stem cell transplantation. Eur J Clin Nutr 66(10):1120–1123PubMed
33.
Yang J et al (2017) Effect of body mass index on overall survival of patients with allogeneic hematopoietic stem cell transplantation. Eur J Clin Nutr 71(6):750–754PubMed
34.
Pereira AZ et al (2021) Impact of obesity and visceral fat on mortality in hematopoietic stem cell transplantation. JPEN J Parenter Enteral Nutr 45(7):1597–1603PubMed
35.
Urbain P et al (2013) Body mass index and bioelectrical impedance phase angle as potentially modifiable nutritional markers are independent risk factors for outcome in allogeneic hematopoietic cell transplantation. Ann Hematol 92(1):111–119PubMed
36.
Urbain P et al (2013) Longitudinal follow-up of nutritional status and its influencing factors in adults undergoing allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 48(3):446–451PubMed
37.
Zama D et al (2020) Enteral nutrition protects children undergoing allogeneic hematopoietic stem cell transplantation from blood stream infections. Nutr J 19(1):29PubMedPubMedCentral
38.
Yang MJ et al (2022) A mindfulness-based stress management program for caregivers of allogeneic hematopoietic stem cell transplant (HCT) patients: Protocol for a randomized controlled trial. PLoS One 17(4):e0266316PubMedPubMedCentral
39.
40.
Blanc KL, Ringden O, Remberger M (2003) A low body mass index is correlated with poor survival after allogeneic stem cell transplantation. Haematologica 88(9):1044–1052PubMed
41.
Jaime-Pérez JC et al (2013) Obesity is associated with higher overall survival in patients undergoing an outpatient reduced-intensity conditioning hematopoietic stem cell transplant. Blood Cell Mol Dis 51(1):61–65
42.
Ren G et al (2018) Impact of body mass index at different transplantation stages on postoperative outcomes in patients with hematological malignancies: a meta-analysis. Bone Marrow Transplant 53(6):708–721PubMed
43.
Espinoza M et al (2016) Nutritional assessment as predictor of complications after hematopoietic stem cell transplantation. Rev Bras Hematol Hemoter 38(1):7–14PubMed
44.
Yu J et al (2020) Obesity is correlated with poor outcome after allogeneic hematopoietic stem cell transplantation in patients with acute leukemia. Jpn J Clin Oncol 50(8):889–896PubMed
45.
Aplenc R et al (2014) Effect of body mass in children with hematologic malignancies undergoing allogeneic bone marrow transplantation. Blood 123(22):3504–3511PubMedPubMedCentral
46.
Schoettler ML et al (2019) Very young children who undergo hematopoietic cell transplantation at weight extremes have inferior overall survival and increased transplant related morality. Biol Blood Marrow Transplant 25(3):S161
47.
Eglseer D et al (2020) Nutritional problems and their non-pharmacological treatment in adults undergoing haematopoietic stem cell transplantation-a systematic review. Eur J Cancer Care (Engl) 29(6):e13298PubMed
48.
Lyu M et al (2021) Comparison of autologous and allogeneic stem cell transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Hematology 26(1):65–74PubMed
49.
Beckstead JW (2014) On measurements and their quality: paper 3: post hoc pooling and errors of discreteness. Int J Nurs Stud 51(3):488–494PubMed
Metadata
Title
Nutritional status and body mass index before hematopoietic stem cell transplantation (HSCT) and associated outcomes: a rapid review
Authors
Rachel Sauls
Acadia W. Buro
Lindsey Montgomery
Marilyn Stern
Farhad Khimani
Sylvia L. Crowder
Publication date
01-01-2024
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 1/2024
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-023-08238-9

Other articles of this Issue 1/2024

Supportive Care in Cancer 1/2024 Go to the issue

Research

A pragmatic dialogue amongst stakeholders on the impact of COVID-19 on Irish cancer patients and healthcare services and lessons learned

Review

Adverse childhood events and mental health problems in cancer survivors: a systematic review

Review

Prehabilitation in radiation therapy: a scoping review

Research

Patient perceptions of altering chemotherapy treatment due to peripheral neuropathy

Research

Incidence and risk factors for febrile neutropenia of patients with diffuse large B-cell lymphoma receiving R-CHOP-21 in China

Research

Burnout profiles among French healthcare professionals caring for young cancer patients
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits