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01-07-2020 | Graft-Versus-Host Disease | Original Article

Effect of the severity of acute graft-versus-host disease on physical function after allogeneic hematopoietic stem cell transplantation

Authors: Ryota Hamada, Tadakazu Kondo, Masanobu Murao, Jyunsuke Miyasaka, Michiko Yoshida, Manabu Nankaku, Junya Kanda, Akifumi Takaori-Kondo, Ryosuke Ikeguchi, Shuichi Matsuda

Published in: Supportive Care in Cancer | Issue 7/2020

Abstract

Purpose

The purpose of this study was to retrospectively investigate the effect of the severity of acute graft-versus-host disease (GVHD) on physical function after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods

76 patients were included as subjects of this study. Severity of acute GVHD was classified according to the method defined by Grucksberg. To evaluate physical function, the knee extensor strength and six-minute walk distance (6MWD) were performed.

Results

Among these patients, 54% developed acute GVHD; of these, 32%, 54%, and 15% of patients had grade I, grade II, and grades III–IV GVHD, respectively. In the grade I–II groups, mild acute GVHD following allo-HSCT resulted in a gradual decline in physical function, which improved at discharge. However, in cases of severe acute GVHD, physical function deteriorated, implementation of rehabilitation became difficult, and the decline in physical function persisted even at discharge.

Conclusion

These results indicate that severe acute GVHD negatively affects physical function leading to longer hospital days because of inadequate rehabilitation interventions.

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Title: Effect of the severity of acute graft-versus-host disease on physical function after allogeneic hematopoietic stem cell transplantation
Authors: Ryota Hamada
Tadakazu Kondo
Masanobu Murao
Jyunsuke Miyasaka
Michiko Yoshida
Manabu Nankaku
Junya Kanda
Akifumi Takaori-Kondo
Ryosuke Ikeguchi
Shuichi Matsuda
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Keywords: Graft-Versus-Host Disease
Graft-Versus-Host Disease
Stem Cell Transplantation
Stem Cell Transplantion
Stem Cell Transplantation
Published in: Supportive Care in Cancer / Issue 7/2020
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-019-05124-1

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