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Open Access 01-10-2019 | Original Article

Kidney volume, kidney function, and ambulatory blood pressure in children born extremely preterm with and without nephrocalcinosis

Authors: Alexander Rakow, Åsa Laestadius, Ulrika Liliemark, Magnus Backheden, Lena Legnevall, Sylvie Kaiser, Mireille Vanpée

Published in: Pediatric Nephrology | Issue 10/2019

Abstract

Background

Reduced kidney volume (KV) following prematurity is a proxy for reduced nephron number and is associated with the development of hypertension and end-stage renal disease in adults. We investigated whether extreme prematurity affects KV, function, and blood pressure in school-aged children and if nephrocalcinosis (NC) developed during the neonatal period had additional effects.

Methods

We investigated 60 children at a mean age of 7.7 years: 20 born extremely preterm (EPT < 28 weeks gestational age with NC (NC+)), 20 born EPT without NC (NC−), and 19 born as full-term infants (control). We measured KV by ultrasound, collected blood and urine samples to evaluate renal function, and measured office and 24-h ambulatory blood pressure (ABPM).

Results

Children born EPT had significantly smaller kidneys (EPT (NC+ NC−) vs control (estimated difference, 11.8 (CI − 21.51 to − 2.09 ml), p = 0.018) and lower but normal cystatin C–based glomerular filtration rate compared with control (estimated difference, − 10.11 (CI − 0.69 to − 19.5), p = 0.035). KV and function were not different between NC+ and NC− groups. Change in KV in relation to BSA (KV/BSA) from the neonatal period to school age showed significantly more EPT children with neonatal NC having a negative evolution of KV (p = 0.01). Blood pressure was normal and not different between the 3 groups. Fifty percent of EPT had a less than 10% day-to-night decline in ABPM.

Conclusions

Kidney growth and volume is affected by EPT birth with NC being a potential aggravating factor. Circadian blood pressure regulation seems abnormal in EPT-born children.

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Title: Kidney volume, kidney function, and ambulatory blood pressure in children born extremely preterm with and without nephrocalcinosis
Authors: Alexander Rakow
Åsa Laestadius
Ulrika Liliemark
Magnus Backheden
Lena Legnevall
Sylvie Kaiser
Mireille Vanpée
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 10/2019
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-019-04293-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Kidney volume, kidney function, and ambulatory blood pressure in children born extremely preterm with and without nephrocalcinosis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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