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01-09-2009 | Editorial Commentary

Urinary tract infections: to prophylaxis or not to prophylaxis?

Authors: Giovanni Montini, Ian Hewitt

Published in: Pediatric Nephrology | Issue 9/2009

Abstract

Urinary tract infections, with or without reflux, are the most frequent reason for long-term antibacterial prophylaxis in infants and children. When one is considering the use of prophylaxis in these children, what is clear from existing published data? Up to 2006 there were a small number of poor quality studies, with no reliable evidence of the effectiveness of antibiotics in preventing recurrent symptomatic urinary tract infections (UTIs). Since then, four randomised controlled studies, to assess the benefits, or lack thereof, of antibiotic prophylaxis, have been published. None has demonstrated a clear benefit. The following conclusions can be drawn: antibiotic prophylaxis is not indicated for children following a first febrile UTI if no or mild grade I or II reflux is present; for higher grade reflux there is no definite conclusion.

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Title: Urinary tract infections: to prophylaxis or not to prophylaxis?
Authors: Giovanni Montini
Ian Hewitt
Publication date: 01-09-2009
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 9/2009
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-009-1213-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Urinary tract infections: to prophylaxis or not to prophylaxis?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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