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01-08-2009 | Original Article

Left ventricular mass in normotensive, prehypertensive and hypertensive children and adolescents

Authors: Stella Stabouli, Vasilios Kotsis, Zoe Rizos, Savvas Toumanidis, Christince Karagianni, Andreas Constantopoulos, Nikos Zakopoulos

Published in: Pediatric Nephrology | Issue 8/2009

Abstract

The purpose of this study was to investigate differences in left ventricular mass index (LVMI) and the prevalence of left ventricular hypertrophy (LVH) in children and adolescents classified as normotensives, prehypertensives and hypertensives by ambulatory blood pressure (BP) levels. A total of 124 consecutive children and adolescents aged 5 to 18 years were analysed. Patients underwent 24 h ambulatory blood pressure monitoring (ABPM) and echocardiography. Hypertensive and prehypertensive subjects had significantly higher LVMI than normotensives (36.8 ± 8.4 g/m^2.7 and 34.1 ± 3.4 g/m^2.7 vs. 29.5 ± 8.3 g/m^2.7, P < 0.01 and P < 0.05, respectively). In multivariate analysis predictors for LVMI were body mass index (BMI) z score and hypertension (R-squared = 0.31). LVMI values in hypertensive subjects were significantly higher than those of normotensives even after adjustment for age, sex and BMI z score. The prevalence of LVH was significantly higher in the prehypertensive compared to normotensive subjects, and was equal to that of the hypertensive subjects. Hypertension and prehypertension in children and adolescents were associated with pathologically elevated LVMI values. If confirmed in a larger group prehypertensive children may be at risk for target organ damage similar to the condition of established hypertension.

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Title: Left ventricular mass in normotensive, prehypertensive and hypertensive children and adolescents
Authors: Stella Stabouli
Vasilios Kotsis
Zoe Rizos
Savvas Toumanidis
Christince Karagianni
Andreas Constantopoulos
Nikos Zakopoulos
Publication date: 01-08-2009
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 8/2009
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-009-1165-2

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Left ventricular mass in normotensive, prehypertensive and hypertensive children and adolescents

Abstract

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