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01-03-2005 | Review

Cardiovascular disease as a late complication of end-stage renal disease in children

Authors: Jaap W. Groothoff, Marc R. Lilien, Nicole C. A. J. van de Kar, Eric D. Wolff, Jean Claude Davin

Published in: Pediatric Nephrology | Issue 3/2005

Abstract

As in older adults, cardiovascular disease is the most important cause of death in adolescents and young adult patients with end-stage renal disease (ESRD) since childhood. This concerns patients on dialysis as well as transplant patients, despite the fact that a long duration of dialysis during childhood is an extra mortality risk factor. Left ventricular hypertrophy (LVH), aortic valve calcification, and increased arterial stiffness, but not increased arterial intima media thickening, are the most frequently observed alterations in young adult survivors with childhood ESRD. In transplanted patients a concentric LVH as a result of chronic hypertension is mostly observed; in dialysis patients a more asymmetric septal LVH is found as a result of chronic volume overload. These results suggest that in children and young adults with ESRD chronic pressure and volume overload, a high calcium-phosphate product, and chronic inflammation, but not dyslipidemia, play a role in the development of cardiovascular disease.

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Title: Cardiovascular disease as a late complication of end-stage renal disease in children
Authors: Jaap W. Groothoff
Marc R. Lilien
Nicole C. A. J. van de Kar
Eric D. Wolff
Jean Claude Davin
Publication date: 01-03-2005
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 3/2005
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-004-1624-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cardiovascular disease as a late complication of end-stage renal disease in children

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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