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01-03-2005 | Review

Genomic and non-genomic actions of sex steroids in the growth plate

Authors: Marcel Karperien, Bram C. J. van der Eerden, Jan Maarten Wit

Published in: Pediatric Nephrology | Issue 3/2005

Abstract

Sex steroids, and particularly estrogens, are important regulators of bone growth and bone mass accrual. For a long time, it was thought that these effects were mainly caused by their modulatory effects on the somatotrophic axis. Data gathered in the past years have challenged this view and it is now widely accepted that many of the effects of sex steroids on growth and bone mass accrual are caused by direct effects on target cells in the growth plate and bone. This review summarizes and discusses some of our latest findings on the expression of sex steroid receptors in the growth plate, the source of the ligands activating these receptors, and their putatitive mechanism of action predominantly focusing on observations in the rat.

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Title: Genomic and non-genomic actions of sex steroids in the growth plate
Authors: Marcel Karperien
Bram C. J. van der Eerden
Jan Maarten Wit
Publication date: 01-03-2005
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 3/2005
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-004-1710-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Genomic and non-genomic actions of sex steroids in the growth plate

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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