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25-10-2022 | Gastrectomy | Original Article

Oncological outcomes of large gastrointestinal stromal tumors treated by laparoscopic resection

Authors: Sheng-Chieh Lin, Hung-Hsuan Yen, Po-Chu Lee, I-Rue Lai

Published in: Surgical Endoscopy | Issue 3/2023

Abstract

Background

The resection of large gastric gastrointestinal stromal tumors (GISTs) by laparoscopic has been controversial. Extending from our prior study, the long-term oncological outcome of laparoscopic resection of large (5–8 cm) gastric GISTs was reported.

Methods

From 2002 to 2018, a consecutive 66 patients with gastric GISTs of 5-8 cm were treated at National Taiwan University Hospital. Among them, 30 patients received open surgery, and 36 received laparoscopic surgery. The clinicopathological data, peri-operative and oncological outcomes were compared between groups.

Results

The clinical demographics including sex, age, BMI, tumor locations and ratio of wedge resection were similar between groups. The mean tumor size was 6.0 ± 0.83 cm versus 6.3 ± 1.07 cm (Open vs. Laparoscopic, p = 0.3). The operation time, blood loss, and post-operative complications, were also similar. The mean hospital stay was shorter in the laparoscopic group (8.8 ± 2.5 days) than in the open group (12.0 ± 8.9 days), though not significantly different. The median follow-up time was 108 ± 58 months (97 ± 50 in laparoscopic group; 122 ± 64 in open group). All except three patients remain disease-free. One in the open group and two in the laparoscopic group had recurrence of tumor, and they were stable of disease under Imatinib treatment. Eight patients died in non-GIST causes during follow-up. The 5-year recurrence-free survival were 100% for the open and 94.2% for the laparoscopic group (p = 0.2).

Conclusion

Our data showed that laparoscopic surgery for gastric GIST between 5 and 8 cm was safe and oncologically feasible.

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Title: Oncological outcomes of large gastrointestinal stromal tumors treated by laparoscopic resection
Authors: Sheng-Chieh Lin
Hung-Hsuan Yen
Po-Chu Lee
I-Rue Lai
Publication date: 25-10-2022
Publisher: Springer US
Keywords: Gastrectomy
Gastrointestinal Stromal Tumor
Gastrectomy
Imatinib
Published in: Surgical Endoscopy / Issue 3/2023
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-022-09693-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Oncological outcomes of large gastrointestinal stromal tumors treated by laparoscopic resection

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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