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Published in: Dysphagia 3/2016

01-06-2016 | Review Paper

Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer

Authors: Suzanne N. King, Neal E. Dunlap, Paul A. Tennant, Teresa Pitts

Published in: Dysphagia | Issue 3/2016

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Abstract

Oncologic treatments, such as curative radiotherapy and chemoradiation, for head and neck cancer can cause long-term swallowing impairments (dysphagia) that negatively impact quality of life. Radiation-induced dysphagia comprised a broad spectrum of structural, mechanical, and neurologic deficits. An understanding of the biomolecular effects of radiation on the time course of wound healing and underlying morphological tissue responses that precede radiation damage will improve options available for dysphagia treatment. The goal of this review is to discuss the pathophysiology of radiation-induced injury and elucidate areas that need further exploration.
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Metadata
Title
Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer
Authors
Suzanne N. King
Neal E. Dunlap
Paul A. Tennant
Teresa Pitts
Publication date
01-06-2016
Publisher
Springer US
Published in
Dysphagia / Issue 3/2016
Print ISSN: 0179-051X
Electronic ISSN: 1432-0460
DOI
https://doi.org/10.1007/s00455-016-9710-1

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