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Journal of Cancer Research and Clinical Oncology

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01-01-2021 | Lung Cancer | Original Article – Cancer Research

Mendelian randomization study indicates lack of causal relationship between physical activity and lung cancer

Authors: Wei Xian, Jiayi Shen, Huaqiang Zhou, Jiaqing Liu, Yaxiong Zhang, Zhonghan Zhang, Ting Zhou, Shaodong Hong, Yunpeng Yang, Wenfeng Fang, Hongyun Zhao, Yan Huang, Li Zhang

Published in: Journal of Cancer Research and Clinical Oncology | Issue 1/2021

Abstract

Background

Previous researches have indicated physical activity (PA) may be associated with lower risk of lung cancer. However, causal relationship between PA and risk of lung cancer is not clear. We aimed to inspect the causal effect of PA on lung cancer.

Methods

We analyzed summary data of accelerator-measured PA and lung cancer from the genome-wide association study (GWAS) using two‐sample Mendelian randomization (MR) method. We obtained summary data of accelerator-measured PA from UK Biobank, data of lung cancer patients from Consortium and International Lung Cancer Consortium (ILCCO) to investigate possible causal effect of PA on lung cancer.

Results

According to result of MR using inverse variance weighted method (IVW), we found that genetically predicted higher PA level did not causally decrease risk of lung cancer (OR 0.95, 95% CI 0.88–1.03, p = 0.238). Results of MR-Egger and weighted median method were consistent with IVW method.

Conclusion

Our mendelian randomization study showed that genetically higher PA is not causally associated with risk of lung cancer. More researches are needed to investigate relationship between PA and lung cancer.

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Title: Mendelian randomization study indicates lack of causal relationship between physical activity and lung cancer
Authors: Wei Xian
Jiayi Shen
Huaqiang Zhou
Jiaqing Liu
Yaxiong Zhang
Zhonghan Zhang
Ting Zhou
Shaodong Hong
Yunpeng Yang
Wenfeng Fang
Hongyun Zhao
Yan Huang
Li Zhang
Publication date: 01-01-2021
Publisher: Springer Berlin Heidelberg
Keywords: Lung Cancer
Lung Cancer
Lung Cancer
Published in: Journal of Cancer Research and Clinical Oncology / Issue 1/2021
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-020-03409-1

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Abstract

Background

Methods

Results

Conclusion

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