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Journal of Cancer Research and Clinical Oncology

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01-01-2010 | Original Paper

The prognostic role of phospho-Src family kinase analysis in tongue cancer

Authors: Ofer Ben-Izhak, Victoria Cohen-Kaplan, Rafael M. Nagler

Published in: Journal of Cancer Research and Clinical Oncology | Issue 1/2010

Abstract

Background

The up regulation of Phospho-Src family kinase oncogene has been correlated with reduced post-operative survival in various cancers but never in tongue cancer.

Methods

We analyzed phospho-Src family kinase in 39 tongue (mobile) cancer patients by immunohistochemistry, compared these results with similar analysis for TUNEL and c-erbB-2 and with both clinical tumor characteristics and patient survival probability rates.

Results

Phospho-Src family kinase overexpression was found in most tongue cancer biopsies (62%), significantly correlating with tumors larger in size (P = 0.05), progression—lymph node metastasis (0.004) and stage (P = 0.05), and correlating with TUNEL (P = 0.01) and c-erbB-2 (P = 0.05) expression rates. At 60 months, survival probability for negative phospho-Src family kinase level (=0) patients was 67%, but 30% for positive phospho-Src family kinase level (>0) patients (P = 0.05).

Conclusions

Inverse correlation between phospho-Src family kinase and patient survival demonstrates the prognostic role of phospho-Src family kinase in tongue cancer. These findings suggest a novel link between phospho-Src family kinase and TUNEL and c-erbB-2 pathways, tilting the balance toward cell proliferation.

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Title: The prognostic role of phospho-Src family kinase analysis in tongue cancer
Authors: Ofer Ben-Izhak
Victoria Cohen-Kaplan
Rafael M. Nagler
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 1/2010
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-009-0633-1

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Abstract

Background

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Conclusions

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