Published in:
01-05-2008 | Original Paper
Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma
Authors:
Hui Wang, Ke Pan, Hua-kun Zhang, De-sheng Weng, Jun Zhou, Jian-jun Li, Wei Huang, Hai-feng Song, Min-shan Chen, Jian-chuan Xia
Published in:
Journal of Cancer Research and Clinical Oncology
|
Issue 5/2008
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Abstract
Purpose
Recent studies have identified polycomb-group gene Bmi-1 as oncogene in the generation of mouse pre-cell lymphomas, and overexpression of Bmi-1 has been found in several human tumor with the disease progress and poor prognosis of the cancer patients.
Methods
In present study, we investigated Bmi-1 expression and its prognostic significance in hepatocellular carcinoma (HCC) by performing immunohistochemical analysis, using a total of 137 HCC clinical tissue samples.
Results
High Bmi-1 expression (Bmi-1 2+ or 3+) was shown in 29.9% cases. The positive immuno-staining of Bmi-1 was not only in well/moderately-differentiated tumor cells, but also in surrounding noncancerous or cirrhotic liver tissue. Bmi-1 expression level did not correlate with any clinicopathological parameters. However, survival analysis showed that the high-Bmi-1 group had a significantly shorter overall survival time than the low-Bmi-1 group (P = 0.047). Multivariate analysis after 24 months revealed that Bmi-1 expression was a significant and independent prognostic parameter (P = 0.002) for HCC patients.
Conclusions
Our study indicated that Bmi-1 could be a candidate biomarker for long-term survival in HCC.