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Published in: European Journal of Pediatrics 10/2015

01-10-2015 | Original Article

Obesity increases the risk of renal involvement in children with Henoch–Schönlein purpura

Authors: Yong-Li Zhao, Zheng-Juan Liu, Xue-Mei Bai, Yu-Chuan Wang, Guo-Hua Li, Xue-Yan Yan

Published in: European Journal of Pediatrics | Issue 10/2015

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Abstract

The main aim of this study was to evaluate the relationship between obesity and renal involvement in children with Henoch–Schönlein purpura (HSP). A retrospective study of 141 pediatric patients with HSP was conducted in our hospital. The clinical data of all patients were collected from the electronic medical record management system from January 2010 to June 2014. The possible risk factors of renal involvement, especially obesity, were analyzed using univariate and multivariate analyses. Renal involvement occurred in 45/141 of the patients. A univariate analysis showed that an age more than 7 years at onset, persistent purpura, obesity, time from symptoms onset to diagnosis more than 14 days, and decreased C3 all increased the risk of renal involvement in HSP. The forward stepwise logistic regression analysis indicated obesity (odds ratio (OR) 4.43, 95 % confidence interval (CI) 1.896 to 10.358), age more than 7 years at onset (OR 2.81, 95 % CI 1.142 to 6.907), and persistent purpura (OR 2.57, 95 % CI 1.119 to 5.909) were independent risk factors for renal involvement.
Conclusions: Our results show that obesity can increase the hazard of renal involvement in children with HSP and reconfirm that older age at onset and persistent purpura are the independent risk factors for renal involvement.
What is Known:
There have been some reports that obesity was associated with the development of renal injury.
It is not clear whether obesity can increase the risk of renal involvement in children with HSP.
What is New:
The main finding of this study is that obesity can increase the hazard of renal involvement in children with HSP.
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Metadata
Title
Obesity increases the risk of renal involvement in children with Henoch–Schönlein purpura
Authors
Yong-Li Zhao
Zheng-Juan Liu
Xue-Mei Bai
Yu-Chuan Wang
Guo-Hua Li
Xue-Yan Yan
Publication date
01-10-2015
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 10/2015
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-015-2547-z

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